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ADA 2017: CV Complications of Diabetes

ADA 2017: CV Complications of Diabetes


  • Cardiovascular Complications of Diabetes: 3 Studies At-a-Glance
    Presented at the American Diabetes Association 77th Scientific Sessions, June 9-13, 2017

  • Prediabetes is a Risk Factor for Congestive Heart Failure Among Middle-aged but Not Older Adults

  • Prediabetes in middle-aged, but not older adults was found to be an independent risk factor for developing congestive heart failure (CHF).

  • Among adults aged younger than 65 years, prediabetes was associated with higher incidence of CHF hospitalization vs those with normoglycemia, with lesser effects found in subjects aged older than 65 years. Conclusion: Prediabetes as an independent risk factor for incident CHF was more prevalent in middle-aged vs older adults. Incidence of CHF increased with longer duration of diabetes. Link to Abstract.

  • Higher Incidence of Cardiovascular Disease Mortality in Prediabetic Individuals Diagnosed by HbA1c than by Fasting Glucose: The Whitehall II Study

  • With poor correlation between fasting plasma glucose (FPG) and HbA1c (A1c) in determining prediabetes, subsequent prognosis for cardiovascular disease (CVD) and mortality may differ depending on diagnostic method.

  • Conclusion: Prediabetic individuals diagnosed with A1c had an almost two-fold higher risk of CVD or death compared to those diagnosed by FPG, suggesting that the ADA threshold for determining impaired fasting glucose is too low. Link to Abstract.


  • Large Weight Loss, Cardiovascular Disease, and Mortality: The ADVANCE Trial

  • While modest weight loss of > 5% is commonly recommended for overweight or obese patients with diabetes, this study determined that large weight loss, sometimes unintentional, may reflect poor prognosis.

  • Conclusion: These findings suggest that large weight loss among patients with diabetes is associated with increased risk of cardiovascular events and mortality, irrespective of age and baseline weight. Link to Abstract.

In this selection of Studies at ADA 77th Scientific Sessions included evaluations of whether prediabetes and the criteria used to determine prediabetes, and large weight loss in diabetics may be factors in cardiovascular disease and mortality.

Comments

Excellent review of current diabetic treatment data. Thank you!

T. Griffin, MD

Thomas E. @

So it's better for a morbidly obese patient weighing 250 pounds to lose 12.5 vs 25 pounds or more?
This makes no sense

Anonymous @

The conclusion is not properly written; it appears if there is a very significant unintentional weight loss in a diabetic with significantly uncontrolled diabetes causing weight loss it means there is significant deficiency of insulin relative to the needs of the body and there is muscle loss going on and not fat loss. These patients are at high risk of cv complications.
In other words as little NH as diabetes is CONTROLLED then more weight will have a better outcome.

Anonymous @

Good review

Daniel @

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