Clinical applications for the most commonly used anticonvulsants are reviewed here, along with complications and recent findings for day-to-day practice. Also: an update on findings from research on anticonvulsants used less often, but which may be potentially beneficial.
In a world in which substance use disorders are no longer suffered in isolation, treating addiction is a challenging journey with obstacles, intermittent failures, and life-altering successes. A poem on drug withdrawal expressed through the eyes of a fellow in addiction medicine.
In the US, suicide is a leading cause of death, ranking third among youths aged 15 to 24. Rates of suicide attempts and death are highest among US Pacific Island indigenous youths. Emergency departments play a key role in suicide prevention, especially in this and other minority populations.
The SSRIs, although principally targeting serotonin transporter, are complex drugs that might work on other neurotransmitter and receptor systems. It is likely worthwhile to look at the effects of other monoamine and neuropeptide systems on the enzymatic machinery cleaving the amyloid precursor protein.