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A&H_Buspirone

A&H_Buspirone

Anxiolytics and Hypnotics


Buspirone (Buspar)
 
Active metabolites
1-Pyrimidinyl-piperazine (1-PP)

Typical adult reference dose
5 mg tid

Half-life
0.5 - 2.5 h; 1-PP: 6.3 h

Adult dose in ESRD
2.5 - 5 mg tid

Half-life in ESRD
1 - 5 h; 1-PP: 9 h

Removed by dialysis
H: no

Comments
Considerable inter- and intra-individual variability in kinetics in ESRD; patients with renal failure may benefit from 25% - 50% dose reduction


 
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