ANTIPSY_Risperidone

March 13, 2012

Antipsychotics Atypical^a

Risperidone (Risperdal)

Active metabolites

9-Hydroxyrisperidone (9ROH)

Typical adult reference dose

1 - 3 mg bid

Half-life

3 - 30 h; 9ROH: 19 h

Adult dose in ESRD

0.5 - 1.5 mg bid

Half-life in ESRD

9ROH: 25 h

Removed by dialysis

H: no; CAPD: no

Comments

Wide variation in clearance noted between poor and extensive metabolizers; clearance of sum of risperidone and 9ROH are reduced by 60% renal failure