In order to improve the outcome of schizophrenia, we must deepen our understanding of its heterogeneous aspect. At the same time, we must search for homogeneous subtypes characterized by consistent clinical aspects so that we may develop specific and more effective treatments. Researchers have long categorized schizophrenia as a syndrome manifested through a number of distinct subtypes that share the same morbid process but have sufficient differences to warrant distinct subtyping (Berman et al., 1995a; Fenton and McGlashan, 1986; Rosen, 1957; Stengel, 1945). Using genetic, neurological, biochemical and outcome markers, research continues to focus on the search for homogeneous subtypes (Goldstein and Tsuang, 1988).
In this article, we will discuss the significance of the obsessive-compulsive (OC) phenomenon in schizophrenia and focus on whether an OC subtype of schizophrenia makes clinical and theoretical sense. One of the yet unanswered questions is whether OC symptoms constitute the expression of schizophrenic psychosis or if they are the manifestation of obsessive-compulsive disorder (OCD). The answer to this question has both theoretical and clinical implications and would affect our understanding about the etiology and physiology of schizophrenia, as well as insights into outcome and treatment.
If OC symptoms in schizophrenia are expressions of OCD and are more than just manifestations of chronic psychosis, the treatment of many patients would be changed to include an anti-obsessional agent (Berman et al., 1995b). Increasing evidence suggests that OC symptoms are not simply expressions of persistent schizophrenic psychosis but that they actually constitute a cluster of symptoms that resembles OCD (Berman et al., 1998). The question then remains whether OC symptoms are manifestations of comorbid OCD or whether they are characteristics of a distinct subtype of schizophrenia.
OC Symptoms in Schizophrenia
The answer to this question has been frequently hindered by the difficulty in differentiating between OCD and psychotic symptoms. Early authors have described the similarity between severe OCD and psychosis (Insel and Akiskal, 1986). For instance, both OCD and psychosis may include absurd or excessive ideas or beliefs. Moreover, when patients with OCD lose insight, their OC symptoms become psychotic; and, similarly, when psychotic symptoms become repetitive, intrusive and egodystonic, patients with schizophrenia begin to experience an OC-like phenomenon.
Consequently, these patients may suffer from obsessions and compulsions that are intertwined with the psychotic process. The current data suggest that a significant number of patients with schizophrenia (up to 50%) have OC-like symptoms coexisting with psychosis and that these symptoms can be easily overlooked by clinicians (Berman et al., 1998).
In order to understand the etiology of this phenomenon in patients with schizophrenia, we need to rely on pharmacologic, neurocognitive, genetic, brain imaging and biochemical data. The data about the significance of OC symptoms in schizophrenia, however, are limited to only a few studies about the phenomenology, epidemiology, psychopharmacology and neurocognition of OC phenomena in this patient population.
Early studies suggested that the association between OC symptoms and schizophrenia was a rare phenomenon and indicated a good outcome (Rosen, 1957; Stengel, 1945). More recent studies, however, have reported that the OC symptoms are seen in a significantly higher number of patients with schizophrenia than had been previously anticipated and that these patients have a poorer outcome. For instance, Fenton and McGlashan (1986) found that approximately 13% (21 out of 163) of patients with schizophrenia had significant OC symptoms and, compared to patients without obsessions or compulsions, were more socially isolated and had longer hospitalizations. Our group found similar results in a sample of patients from a community mental health center (Berman et al., 1995a). We found that approximately 25% of our patients had OC symptoms and that these patients with OC symptoms had an earlier onset of illness, were more socially isolated, spent more time in the hospital, had worse employment history and were thought by therapists to have a lower level of functioning. These findings were supported later by Bermanzohn et al. (1997) who reported that 20% to 50% of patients with schizophrenia had OC symptoms and that the presence of such symptoms indicated poor outcome. A similarly high prevalence (45%) was found by our group in a neuropsychological study in patients hospitalized at a long-term psychiatric hospital (Berman et al., 1998).
1.Berman I, Chang HH, Klegon DA (1999), Is there a distinct subtype of obsessive-compulsive schizophrenia? Psychiatric Annals 30(10):649-652.
2.Berman I, Kalinowski A, Berman SM et al. (1995a), Obsessive and compulsive symptoms in chronic schizophrenia. Compr Psychiatry 36(1):6-10.
3.Berman I, Merson A, Viegner B et al. (1998), Obsessions and compulsions as a distinct cluster of symptoms in schizophrenia: a neuropsychological study. J Nerv Ment Dis 186(3):150-156.
4.Berman I, Sapers BL, Chang HH et al. (1995b), Treatment of obsessive-compulsive symptoms in schizophrenic patients with clomipramine. J Clin Psychopharmacol 15(3):206-210.
5.Bermanzohn PC, Porto L, Arlow PB et al. (1997), Obsessions and delusions: separate and distinct, or overlapping? CNS Spectrums 2(3):58-61.
6.Breese GR, Baumeister AA, McCown TJ et al. (1984), Behavioral differences between neonatal and adult 6-hydroxydopamine-treated rats to dopamine agonists: relevance to neurological symptoms in clinical syndromes with reduced brain dopamine. J Pharmacol Exp Ther 231(2):343-354.
7.Fenton WS, McGlashan TH (1986), The prognostic significance of obsessive-compulsive symptoms in schizophrenia. Am J Psychiatry 143(4):437-441.
8.Goldstein J, Tsuang M (1988), The process of subtyping schizophrenia: strategies in search for homogeneity. In: Handbook of Schizophrenia, Vol. 3: Nosology, Epidemiology and Genetics of Schizophrenia. Amsterdam: Elsevier Science Publishers, pp63-83.
9.Insel TR, Akiskal HS (1986), OCD with psychotic features: a phenomenologic analysis. Am J Psychiatry 143:1527-1533.
10.Jackson D, Bruno JP, Stachowiak MK, Zigmond MJ (1988), Inhibition of striatal acetylcholine release by serotonin and dopamine after the intracerebral administration of 6-hydroxydopamine to neonatal rats. Brain Res 457(2):267-273.
11.Karno M, Golding JM, Sorenson SB, Burnam MA (1988), The epidemiology of obsessive-compulsive disorder in five US communities. Arch Gen Psychiatry 45(12):1094-1099.
12.Kurokawa K, Tanino R (1997), Effectiveness of clomipramine for obsessive-compulsive symptoms and chronic pain in two patients with schizophrenia. J Clin Psychopharmacol 17(4):329-330 [letter].
13.McDougle CJ, Epperson CN, Pelton GH et al. (2000), A double-blind, placebo-controlled study of risperidone addition in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder. Arch Gen Psychiatry 57(8):794-801.
14.Rosen I (1957), The clinical significance of obsessions in schizophrenia. J Ment Sci 103:773-785.
15.Stengel E (1945), A study of some clinical aspects of the relationship between obsessional neurosis and psychotic reaction types. J Ment Sci 41:166-187.
16.Zohar J, Kaplan Z, Benjamin J (1993), Clomipramine treatment of obsessive compulsive symptomatology in schizophrenic patients. J Clin Psychiatry 54(10):385-388.