SAN DIEGO, May 24 -- When attention deficit hyperactivity disorder meets bipolar disorder in an adult, the diagnosis is hard and the course is poorly understood but the co-morbidity appears to exacerbate matters, researchers said here.

A systematic review of rates of bipolar disorder and ADHD in adults revealed that co-morbidity ranges anywhere from about 5% to 47%, reported Aliza P. Wingo, M.D., and S. Nassir Ghaemi, M.D., M.P.H., of Emory University in Atlanta.

But patients with the co-morbid conditions may benefit from the addition of bupropion (Wellbutrin) to their antimanic agents, said Dr. Wingo, who co-authored the study with Dr. Ghaemi.

Co-morbid bipolar disorder and ADHD makes the treatment approach somewhat tricky, Dr. Wingo said at a poster session at the American Psychiatric Association meeting here.

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