A meta-analysis recently published in the Journal of Clinical Psychiatry sheds new light on the safety and efficacy of antidepressants in the acute treatment of bipolar disorder.
The article by Sidor and colleagues1 is noteworthy because, as Dr Ronald Pies, comments: antidepressants are the most common drug treatment in bipolar disorder, but they are probably the least well validated.
Dr Pies has nominated the Sidor article as one of the "Top Papers of the Year."
We've invited Dr Pies, editor emeritus of Psychiatric Times, to explore the implications of this study. Dr Pies is professor of psychiatry at SUNY Upstate Medical University in Syracuse and also Clinical Professor of Psychiatry at Tufts University School of Medicine in Boston. In the next 10 minutes or so, he will also look at what he calls ARAD—antidepressant-induced agitation and dysphoria, which the meta-analysis did not fully examine.
|Dr Pies's Top Paper of the Year: Antidepressants for Acute Treatment of Bipolar Disorder|
Dr Pies's Top Paper of the Year: Antidepressants for Acute Treatment of Bipolar Disorder
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Read the abstract of the original Journal of Clinical Psychiatry article here:
Antidepressants for Acute Treatment of Bipolar Disorder