What do physicians intend by the term “disease”? The recent IOM report on “systemic exertion intolerance disease” (formerly known as chronic fatigue syndrome) casts this question in a new light and has many practical implications for patients, physicians, and third-party payers.
The SSRIs, although principally targeting serotonin transporter, are complex drugs that might work on other neurotransmitter and receptor systems. It is likely worthwhile to look at the effects of other monoamine and neuropeptide systems on the enzymatic machinery cleaving the amyloid precursor protein.
As clinicians, we can daily apply knowledge learned from a few patients with pure amnesia to patients we see often—those who have memory deficits, such as so-called Mild Cognitive Impairment and neurodegenerative diseases, such as Alzheimer's.