To identify what psychiatrists and other physicians may need to know about recent studies in internal medicine, Monique Yohanan, MD, MPH--a physician editor at Epocrates, Inc-- reviewed several articles published during the last year that she considers newsworthy and most likely to influence clinical practice. Dr Yohanan is board-certified in internal medicine, geriatrics, and hospice and palliative care.
In a well-attended presentation at the American Psychiatric Association’s recent annual meeting, Yohanan listed articles with a “special focus on topics common to patients with comorbid psychiatric and medical illness.”
Drug trials
Yohanan selected a study by Bourgeois and colleagues’ study on drug trial outcome reporting.1 The researchers described characteristics of drug trials listed in www.ClinicalTrials.gov and examined whether the funding source of these trials is associated with favorable published outcomes. They looked at safety and efficacy trials conducted between 2000 and 2006 for antidepressants and antipsychotics as well as anticholesteremics, proton-pump inhibitors, and vasodilators.
Of 546 drug trials, 346 (63%) were primarily funded by industry; 74 (14%) were funded by government sources and 126 (23%) were funded by nonprofit or nonfederal organizations. Trials funded by industry were more likely to be phase 3 or 4 trials.
Overall, 362 (66.3%) trials had published results. Industry-funded trials reported positive outcomes in 85.4% of publications, compared with 50.0% for government-funded trials and 71.9% for nonprofit or non-federal organization-funded trials (P < 0.001). Trials funded by nonprofit or non-federal sources with industry contributions were also more likely to report positive outcomes than those without industry funding (85.0% vs 61.2%; P = 0.013). The researchers concluded that as regards registered drug trials, those funded by industry were less likely to be published within 2 years of study completion and were more likely to report positive outcomes than were trials funded by other sources.
The issue of stopping clinical trials early, according to Yohanan, was explored in de Lorgeril and colleagues’2 revisiting of the JUPITER (Justification for the Use of Statins in Primary Prevention) trial and in Bassler and colleagues’3 article, which concluded that truncated randomized controlled trials were associated with greater effect sizes than RCTs not stopped early.
Screening and treatment studies
Yohanan also discussed:
o A study of the effects of mammography screening on breast cancer mortality by Kalager and colleagues.4
o A meta-analysis of 6 randomized controlled trials of prostate cancer screening involving 387,286 asymptomatic men by Djulbegovic et al.5
o Risks for false-positive results on lung cancer screening tests by Croswell.6
o The use of rosiglitazone(Drug information on rosiglitazone) (Avandia) or pioglitazone(Drug information on pioglitazone) (Actos) for diabetes, and the risk of acute myocardial infarction and other adverse events as studied by Graham and associates.7
o An updated meta-analysis of rosiglitazone studies by Nissen and coworkers.8
Pointing to the high prevalence of type 2 diabetes and the need for better treatment approaches, Yohanan reviewed 4 journal articles on the ACCORD (Action to Control Cardiovascular Risk in Diabetes) clinical trial.9-12 The trial included 10,251 participants, making it one of the largest studies ever conducted in adults with type 2 diabetes. Because patients with type 2 diabetes are at high risk for such cardiovascular events as heart attack and stroke, the trial tested 3 possible treatment methods for lowering the risk.
Yohanan ended her presentation with a discussion of inflammatory factors,13,14 vitamins and supplements (covered in an earlier article15), and the effects of omega-3 fatty acids on cardiovascular disease.16-18
