Psychiatric Times.

Suicide Risk and Lethality of Attempts Linked to Low Levels of MHPG

by Myra Partridge | December 1, 2009

Low levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) in patients with major depressive disorder (MDD) or bipolar depression were shown to be associated with increased risk of suicide attempts. Hanga Galfalvy, PhD, assistant professor of clinical neurobiology at Columbia University and the New York State Psychiatric Institute, New York, and her colleagues found that patients with the lowest levels of MHPG at baseline were more likely to commit highly lethal suicidal acts.¹

In this study, 184 drug-free patients with MDD or bipolar disorder underwent lumbar puncture and assays of cerebrospinal fluid (CSF) levels of MHPG. Depressive and suicidal symptoms were also assessed. Of these patients, 101 reported previous suicide attempts. Follow-up interviews were conducted at 3 months and 1 year.

Within the 1-year follow-up, 27 patients attempted suicide, and 2 of these attempts were fatal. Galfalvy reported that in all patients, for each 10 pmol/mL lower CSF MHPG level at baseline, the risk of suicidality increased by 22%. In addition, patients with the lowest levels of MHPG at baseline (mean, 32 pmol/mL) were shown to commit a more lethal suicide actthan patients with higher levels of MHPG at baseline (mean MHPG at baseline, 49 pmol/mL).

Galfalvy concluded that the results of this study indicate the potential for biomarkers to identify patients at risk for highly lethal suicide attempts.

Reference
1. Galfalvy H, Currier D, Oquendo MA, et al. Lower CSF MHPG predicts short-term risk for suicide attempt. Int J Neuropsychopharmacol. 2009;12:1327-1335.

FROM PHYSICIANS PRACTICE

Tax Schemes Every Physician Should Avoid
Ike Devji, JD, January 31, 2012
The next 60 days marks the final push to sell physicians across the United States tax plans of both good and questionable value.

Boosting Collections at Your Medical Practice: Whose Job Is It?
P.J. Cloud-Moulds, January 28, 2012
Embrace the relationship between your billing company and your medical practice staff.

Managing Difficult Medical Practice Employees
Shelly K. Schwartz, January 27, 2012
Tips for transforming immature staff members into great employees.

Prevent Physician Distraction When Using mHealth Technology
Aubrey Westgate, January 25, 2012
As more and more physicians use handheld mobile technology in their day-to-day work, some critics are raising concerns about “distracted doctoring.”

Can That Applicant Do the Job at Your Medical Practice?
Karen Zupko, January 25, 2012
If like many communities, yours has significant numbers of non-English speaking people with whom neither you nor your staff are able to converse, your practice is at a serious disadvantage.

Suicide Risk and Lethality of Attempts Linked to Low Levels of MHPG

Join the Conversation