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Psychiatric Times. Vol. 26 No. 12
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Obesity and Psychiatric Disorders

Associations—and Best Treatment Options

by Danielle Barry, PhD and Nancy M. Petry, PhD | December 5, 2009
Dr Barry is assistant professor and Dr Petry is professor at the University of Connecticut School of Medicine in Farmington. Dr Barry has no conflicts of interest concerning the subject matter of this article. Dr Petry reports that she has provided expert testimony to Dechert LLP.

Behavioral treatment for obesity

In light of the increasing prevalence of overweight and obesity in the general population and elevated prevalence among individuals with a variety of psychiatric disorders, psychiatrists frequently encounter patients who are overweight or obese. They are also quite likely to deal with patients who are experiencing weight gain in response to psychiatric medications.34 There is evidence that most physicians, including psychiatrists, have not received adequate training to counsel patients regarding obesity and options for treatment.35

Behavioral treatments for obesity generally include 3 components: dietary change; increased physical activity; and behavior therapy techniques, such as goal-setting, selfmonitoring, stimulus control, and behavioral contracting.36 In addition to weight loss itself, a goal of behavioral interventions is to introduce lifestyle changes that increase the likelihood that weight loss will be maintained.37 A typical behavioral weight loss program includes 12 to 16 lessons that cover specific strategies, such as recording daily food and calorie intake, avoiding triggers for unhealthy eating, increasing physical activity, obtaining social and family support, and modifying thoughts and emotions that undermine weight loss.38 Behavioral interventions generally result in weight losses of about 8% to 10% of initial body weight.39

Effect of psychiatric disorders on obesity treatment

Patients with comorbid obesity and psychiatric conditions may have difficulty with adhering to weight loss treatment recommendations. Depression or anxiety may interfere with the ability to adopt new behaviors—particularly those that require effort, such as preparing healthier meals or exercising. There is evidence that weight management patients with major depressive disorder lose less weight than their counterparts without depression.40 Poor impulse control associated with ADHD and ASPD can undermine self-control efforts as well.28

Patients who struggle with overweight and obesity may be reluctant to take medications that will further contribute to weight gain, or they may discontinue treatment prematurely if weight gain occurs.41 Sensitivity to these concerns can allow psychiatrists to anticipate challenges and barriers to effective treatment of psychiatric conditions. Bariatric surgery is becoming an increasingly popular treatment for severe obesity. Psychiatric evaluations to assess patients' ability to adhere to the behavioral changes required to benefit from surgery are an important part of the treatment process.42

Treating obese patients with psychiatric disorders

Behavioral assessment of obese patients can identify psychiatric conditions that might interfere with treatment.43 Experts recommend treating depression before starting patients on a weight loss program, although there is also evidence that successful treatment of obesity can lead to significant improvement in mood.34 Exercise can improve mood, and it is a vital component of a successful weight loss intervention. Thus, introducing exercise during treatment for depression can give patients a head start on improving health before they begin a weight loss program.

Patients with anxiety disorders may become alarmed by the physical sensations they experience during exercise. Many require a gradual increase in exercise intensity to learn that heart rate and respiration will return to normal after exertion. Anxious patients may also need encouragement and even gradual exposure to overcome avoidance of behaviors that trigger anxiety, such as weighing themselves or keeping records of weight or food intake.

Patients with ADHD are likely to have difficulty adopting many weight loss strategies, particularly those like self-monitoring of food intake that rely on the ability to keep organized records and make entries on a regular basis. It may be necessary to work with these patients to develop routines for planning meals, finding time for regular exercise, and organizing food diaries and other self-monitoring materials.

Concern about the increased prevalence and negative health effects of obesity continues to grow. Greater understanding of psychiatric comorbidity may facilitate the development of more effective prevention and treatment interventions.

 

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Evidence Based References

Fabricatore AN. Behavior therapy and cognitivebehavioral therapy of obesity: is there a difference? J Am Diet Assoc. 2007;107:92-99.

Wadden TA, Osei S. The treatment of obesity: an overview. In: Wadden TA, Stunkard AJ, eds. Handbook of Obesity Treatment. New York: The Guilford Press; 2002:229-248.

References

1. World Health Organization. Obesity: Preventing and Managing the Global Epidemic. Geneva: WHO; 1998.

2. Hedley AA, Ogden CL, Johnson CL, et al. Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002. JAMA. 2004;291:2847-2850.

3. Barry D, Pietrzak RH, Petry NM. Gender differences in associations between body mass index and DSM-IV mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Ann Epidemiol. 2008;18:458-466.

4. Baumeister H, Härter M. Mental disorders in patients with obesity in comparison with healthy probands. Int J Obes (Lond). 2007;31:1155-1164.

5. Petry NM, Barry D, Pietrzak RH, Wagner JA. Overweight and obesity are associated with psychiatric disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Psychosom Med. 2008;70:288-297.

6. Scott KM, Bruffaerts R, Simon GE, et al. Obesity and mental disorders in the general population: results from the world mental health surveys. Int J Obes (Lond). 2008;32:192-200.

7. Carpenter KM, Hasin DS, Allison DB, Faith MS. Relationships between obesity and DSM-IV major depressive disorder, suicide ideation, and suicide attempts: results from a general population study. Am J Public Health. 2000;90:251-257.

8. Magnusson PK, Rasmussen F, Lawlor DA, et al. Association of body mass index with suicide mortality: a prospective cohort study of more than one million men. Am J Epidemiol. 2006;163:1-8.

9. Carr D, Friedman MA. Is obesity stigmatizing? Body weight, perceived discrimination, and psychological well-being in the United States. J Health Soc Behav. 2005;46:244-259.

10. Kessler RC, Mickelson KD, Williams DR. The prevalence, distribution, and mental health correlates of perceived discrimination in the United States. J Health Soc Behav. 1999;40:208-230.

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12. Andreyeva T, Puhl RM, Brownell KD. Changes in perceived weight discrimination among Americans, 1995-1996 through 2004-2006. Obesity (Silver Spring). 2008;16:1129-1134.

13. Jones F, O’Connor DB, Conner M, et al. Impact of daily mood, work hours, and iso-strain variables on self-reported health behaviors. J Appl Psychol. 2007; 92:1731-1740.

14. Kaplan HI, Kaplan HS. The psychosomatic concept of obesity. J Nerv Ment Dis. 1957;125:181-201.

15. Greeno CG, Wing RR. Stress-induced eating. Psychol Bull. 1994;115:444-464.

16. Larsen JK, van Strien T, Eisinga R, Engels RC. Gender differences in the association between alexithymia and emotional eating in obese individuals. J Psychosom Res. 2006;60:237-243.

17. Bornstein SR, Schuppenies A, Wong ML, Licinio J. Approaching the shared biology of obesity and depression: the stress axis as the locus of gene-environment interactions. Mol Psychiatry. 2006;11:892-902.

18. Barry D, Petry NM. Associations between body mass index and substance use disorders differ by gender: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Addict Behav. 2009;34:51-60.

19. John U, Meyer C, Rumpf HJ, Hapke U. Relationships of psychiatric disorders with overweight and obesity in an adult general population. Obes Res. 2005;13:101-109.

20. Kalarchian MA, Marcus MD, Levine MD, et al. Psychiatric disorders among bariatric surgery candidates: relationship to obesity and functional health status. Am J Psychiatry. 2007;164:328-334, 374.

21. Kleiner KD, Gold MS, Frost-Pineda K, et al. Body mass index and alcohol use. J Addict Dis. 2004;23: 105-118.

22. Warren M, Frost-Pineda K, Gold M. Body mass index and marijuana use. J Addict Dis. 2005;24:95-100.

23. McIntyre RS, McElroy SL, Konarski JZ, et al. Substance use disorders and overweight/obesity in bipolar I disorder: preliminary evidence for competing addictions. J Clin Psychiatry. 2007;68:1352-1357.

24. Volkow ND, Fowler JS, Wang GJ. The addicted human brain: insights from imaging studies. J Clin Invest. 2003;111:1444-1451.

25. Comings DE, Blum K. Reward deficiency syndrome: genetic aspects of behavioral disorders. Prog Brain Res. 2000;126:325-341.

26. Wang GJ, Volkow ND, Logan J, et al. Brain dopamine and obesity. Lancet. 2001;357:354-357.

27. Blum K, Cull JG, Braverman ER, Comings DE. Reward Deficiency Syndrome. Am Sci. 1996;84:132-145.

28. Goldstein RB, Dawson DA, Stinson FS, et al. Antisocial behavioral syndromes and body mass index among adults in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Compr Psychiatry. 2008;49:225-237.

29. Altfas JR. Prevalence of attention deficit/hyperactivity disorder among adults in obesity treatment. BMC Psychiatry. 2002;2:9.

30. Holtkamp K, Konrad K, Müller B, et al. Overweight and obesity in children with Attention-Deficit/Hyperactivity Disorder. Int J Obes Relat Metab Disord. 2004;28:685-689.

31. Anderson SE, Cohen P, Naumova EN, Must A. Relationship of childhood behavior disorders to weight gain from childhood into adulthood. Ambul Pediatr. 2006;6:297-301.

32. Susce MT, Villanueva N, Diaz FJ, de Leon J. Obesity and associated complications in patients with severe mental illnesses: a cross-sectional survey. J Clin Psychiatry. 2005;66:167-173.

33. Allison DB, Mentore JL, Heo M, et al. Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry. 1999;156:1686-1696.

34. Stunkard AJ, Faith MS, Allison KC. Depression and obesity. Biol Psychiatry. 2003;54:330-337.

35. Jay M, Gillespie C, Ark T, et al. Do internists, pediatricians, and psychiatrists feel competent in obesity care? Using a needs assessment to drive curriculum design. J Gen Intern Med. 2008;23:1066-1070.

36. Fabricatore AN. Behavior therapy and cognitive-behavioral therapy of obesity: is there a difference? J Am Diet Assoc. 2007;107:92-99.

37. Diabetes Prevention Program (DPP) Research Group. The Diabetes Prevention Program (DPP): description of lifestyle intervention. Diabetes Care. 2002;25:2165-2171.

38. Friedman MA, Brownell KD. A comprehensive treatment manual for the management of obesity. In: Van Hasselt VB, Hersen M, eds. Sourcebook of Psychological Treatment Manuals for Adult Disorders. New York: Springer; 1996:375-422.

39. Wadden TA, Osei S. The treatment of obesity: an overview. In: Wadden TA, Stunkard AJ, eds. Handbook of Obesity Treatment. New York: Guilford Press; 2002:229-248.

40. Pagoto S, Bodenlos JS, Kantor L, et al. Association of major depression and binge eating disorder with weight loss in a clinical setting. Obesity (Silver Spring). 2007;15:2557-2559.

41. Fava M. Weight gain and antidepressants. J Clin Psychiatry. 2000;61(suppl 11):37-41.

42. Walfish S, Vance D, Fabricatore AN. Psychological evaluation of bariatric surgery applicants: procedures and reasons for delay or denial of surgery. Obes Surg. 2007;17:1578-1583.

43. Wadden TA, Phelan S. Behavioral assessment of the obese patient. In: Wadden TA, Stunkard AJ, eds. Handbook of Obesity Treatment. New York: Guilford Press; 2002:186-226.


 
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