TRI_Amitriptyline

March 13, 2012

Antidepressants Tricyclics

Amitriptyline (Elavil)

Active metabolites

Nortriptyline, hydroxy-amitriptyline, hydroxy-nortriptyline

Typical adult reference dose

25 mg q8h

Half-life

32 - 40 h

Adult dose in ESRD

10 - 25 mg q8 - 12h (or qhs only for insomnia or neuropathic pain)

Half-life in ESRD

Active metabolites likely prolonged; elevated conjugated metabolites in renal failure; probably no difference in dosing

Removed by dialysis

H: no; CAPD: no

Comments

Use of TDM with level of 75 - 175 µg/L may guide therapy for depression

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TRI_Amitriptyline

Antidepressants Tricyclics

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