TRI_Desipramine

March 13, 2012

Antidepressants Tricyclics

Desipramine (Norpramin)

Active metabolites

2-Hydroxy-desipramine (2-OHD)

Typical adult reference dose

100 - 200 mg/d

Half-life

12 - 54 h; 2-OHD: 22 h

Adult dose in ESRD

75 - 125 mg/d

Half-life in ESRD

Active metabolites likely prolonged

Removed by dialysis

H: no; CAPD: no

Comments

Effective in small trial for depression; use of TDM with level of 100 - 160 µg/L may guide therapy for depression; unconjugated amine and hydroxy metabolites not removed by dialysis

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TRI_Desipramine

Antidepressants Tricyclics

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