ANTIPSY_Ziprasidone

March 14, 2012

Antipsychotics Atypical^a

Ziprasidone (Geodon)

Active metabolites

Inactive metabolites

Typical adult reference dose

20 - 80 mg bid

Half-life

7 h

Adult dose in ESRD

10 - 80 mg bid

Half-life in ESRD

Removed by dialysis

Comments

Dose adjustment not necessary for CrCl 10 - 60 mL/min per manufacturer; some clinicians recommend avoiding in ESRD because of prolonged QT interval and risk of life-threatening arrhythmias that may be higher with electrolyte shift

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