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Psychiatric Times. Vol. 21 No. 11
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Psychotherapy and Combined Therapy for Depressive Disorders in Later Life

By Francesca Cannavo Antognini, Ph.D., and James M. Ellison, M.D., M.P.H.
| October 1, 2004
Dr. Antognini is director of psychotherapy and geropsychology training for the geriatric service at McLean Hospital in Belmont, Mass., and is clinical instructor at Harvard Medical School. Dr. Ellison is the clinical director of the Geriatric Psychiatry Service at McLean Hospital in Belmont, Mass., and an associate professor of psychiatry at Harvard Medical School. He specializes in the pharmacotherapy and in the treatment of late-life depression and memory disturbances.

Case Study

The following case study illustrates some aspects of both the complexity and the feasibility of offering psychotherapy in combination with medications in treating an older adult with depression.

"Ms. O" is a 71-year-old widow who has suffered for the past 16 years from recurrent MDD. Her first episode of depression followed the simultaneous occurrence of her husband's sudden death and her own job loss. Ms. O, who had a significant family history of mood disorders, took antidepressant medication for a number of years under the care of a psychiatrist who saw her approximately bimonthly. During this time she was admitted repeatedly to the same psychiatric unit for suicidal ideation, with an actual suicide attempt on one occasion.

During her latest admission, a major re-evaluation of her pharmacotherapy was initiated and she received, for the first time, a form of cognitive-behavioral therapy (CBT) adapted for older adults. At first, Ms. O was skeptical about beginning a course of psychotherapy. Having taken a college psychology course in the early 1950s she thought of psychotherapy as equivalent to psychoanalysis and did not see the relevance of "talk therapy" to her condition. An explanation of the therapeutic process, however, emphasized how CBT would focus on her current thought processes with only brief forays into the distant past. The therapist's identification of specific and realistic therapeutic goals proved reassuring enough that she was willing to begin. Therapy with Ms. O involved a frank examination of her maladaptive cognitions, repeated exploration of alternative cognitions and practice in cognitive restructuring.

Ms. O's natural intelligence and her strong alliance with her therapist, who continued with her through successive stages of care at the same facility, maximized her use of the process.

With the help of her therapist, Ms. O identified a connection between her suicidal ideation and feelings of anger that, because of family dynamics, had been distressing for her to experience or express. She was helped by interpretation of her self-destructive thoughts as anger turned against herself, and by correction of her cognitive distortions regarding the triggers of her anger and the power of her feelings. She was able to switch from thinking of her anger as uncontrollable and destructive to viewing it as a helpful indication of an internal need state. She was also prescribed behavioral steps to increase her assertiveness to better meet her needs.

Concurrent with her psychotherapy sessions, Ms. O received antidepressant and low-dose antipsychotic medications. After discharge from the hospital she continued her psychotherapeutic work and remained in treatment for over a year with very positive results. On a few occasions, feeling "well," Ms. O attempted to "cut back" on her psychotherapy and, on other occasions, negotiated a change in medication with her psychopharmacologist. Ironically, her resistance to psychotherapy seemed on occasion to flare up when she felt some degree of benefit, as she feared her dependency on the process. She eventually began, however, to see a palpable benefit from continuing both psychotherapy and medication. What she learned about her resistance to treatment in psychotherapy added an extra dimension to simple psychoeducation about the importance of adherence to a medication regimen. In addressing feelings about her treatment, she also gained experience in problem solving and in cognitive restructuring. These skills served her well in other areas of her life.

Conclusion

Although practical barriers may on occasion make an integrated treatment impractical, the combination of psychotherapy with antidepressant medication should increasingly be recognized as a standard for effective treatment of older adults with minor or major depressions. The recent resurgence in enthusiasm for psychotherapy training among psychiatric residents as well as new geriatric specialty training programs for nurses, social workers or psychologists offer hope that an increasing number of appropriately trained psychotherapists may become available. By increasing mental health and primary care awareness of the potential value of combined treatment, practice can be brought into conformance with expert consensus recommendations, and psychotherapy co-administered with pharmacotherapy can become a standard treatment approach for depressive disorders in the later years.

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References
1. Alexopoulos GS, Katz IR, Reynolds CF et al. (2001), The expert consensus guideline series: pharmacotherapy of depressive disorders in older patients. Postgrad Med (special issue):1-86.
2. Alexopoulos GS, Raue P, Arean P (2003), Problem-solving therapy versus supportive therapy in geriatric major depression with executive dysfunction. Am J Geriatr Psychiatry 11(1):46-52.
3. Beck AT, Rush AJ, Shaw BF, Emery G (1979), Cognitive Therapy of Depression. New York: Guilford Press.
4. Freud S (1924), A short account of psycho-analysis. In: Standard Edition of the Complete Psychological Works of Sigmund Freud, Vol. 19, Riviere J, trans. London: Hogarth Press, pp191-209.
5. Gerson S, Belin TR, Kaufman A et al. (1999), Pharmacological and psychological treatments for depressed older patients: a meta-analysis and overview of recent findings. Harv Rev Psychiatry 7(1):1-28.
6. Klerman GL, Weissman MM, Rounseville BJ, Chevron E (1984), Interpersonal Psychotherapy of Depression. New York: Basic Books.
7. Lenze EJ, Dew MA, Mazumdar S et al. (2002), Combined pharmacotherapy and psychotherapy as maintenance treatment for late-life depression: effects on social adjustment. Am J Psychiatry 159(3):466-468.
8. Meichenbaum DH (1972), Cognitive modification of test anxious college students. J Consult Clin Psychol 39(3):370-380.
9. Nezu AM (1986), Efficacy of a social problem-solving therapy approach for unipolar depression. J Consult Clin Psychol 54(2):96-102.
10. Reynolds CF 3rd, Frank E, Kupfer DJ et al. (1996), Treatment outcome in recurrent major depression: a post hoc comparison of elderly ("young old") and midlife patients. Am J Psychiatry 153(10):1288-1292.
11. Reynolds CF 3rd, Frank E, Perel JM et al. (1999), Nortriptyline and interpersonal psychotherapy as maintenance therapies for recurrent major depression: a randomized controlled trial in patients older than 59 years. JAMA 281(1):39-45 [see comments].
12. Scogin F, McElreath L (1994), Efficacy of psychosocial treatments for geriatric depression: a quantitative review. J Consult Clin Psychol 62(1):69-74.
13. Thase ME, Greenhouse JB, Frank E et al. (1997), Treatment of major depression with psychotherapy or psychotherapy-pharmacology combinations. Arch Gen Psychiatry 54(11):1009-1015 [see comment].
14. Wolpe J (1969), The Practice of Behavior Therapy. New York: Pergamon Press.


 
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