"There seems to be a class effect for some adverse effects in body weight, body composition and related metabolic indices," he said. Also, "there is a differential effect, across agents, but all seem to be able to induce adverse effects at least in the first three months of treatment, so one has to carefully weigh the options. We are collecting data on six-, nine- and 12-month time points to really see where some of these changes level off. It seems some agents that have adverse changes early on level off much earlier than some other medications, which is the reason that in some switch studies medications come off nearly weight neutral, while others still induce some of these adverse changes."
References
Correll CU, Olshanskiy V, Mughal T et al. (2005a), Prospective study of second-generation antipsychotic-induced insulin resistant in antipsychotic-naive children and adolescents. Presented at the XX International Congress on Schizophrenia Research. Savannah, Ga.; April 2-6.
Correll CU, Parikh UH, Mughal T et al. (2005b), Dyslipidemia in antipsychotic-naive youngsters treated with atypical antipsychotics. Presented at the 60th Annual Meeting of the Society of Biological Psychiatry. Atlanta; May 19-21.
Correll CU, Parikh UH, Mughal T et al. (2005c), Effect of past treatment exposure on risk estimation of atypical antipsychotic-induced body composition changes in children and adolescents. Presented at the 60th Annual Meeting of the Society of Biological Psychiatry. Atlanta; May 19-21.
Olshanskiy V, Malhotra AK, Parikh UH et al. (2005), New-onset dyslipidemia in children and adolescents treated with second-generation antipsychotics. Presented at the XX International Congress on Schizophrenia Research. Savannah, Ga.; April 2-6.
