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Psychiatric Times. Vol. 24 No. 7
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Group Therapy and Cancer Survival-- Where Does the Evidence Lie in 2007?

By Tiffany Floyd, PhD, Barbara Lubrano di Ciccone, MD, and David W. Kissane, MD | June 1, 2007
Dr Floyd is a research fellow, Dr Lubrano di Ciccone is a psychiatrist, and Dr Kissane is chair, department of psychiatry and behavioral sciences at Memorial Sloan-Kettering Cancer Center in New York. They report no conflicts of interest concerning the subject matter of this article.

Future directions

Might specific subgroups of women be more likely to benefit from SEGT, such as women with specific personality characteristics or interpersonal styles?1 To date, there have been no studies of SEGT that have attempted to identify how personality and attachment styles might interact with group treatment in order to predict outcomes.

Another notable gap in the current literature has been the lack of representation of women from racial and ethnic minority backgrounds. This is particularly unfortunate given the well-documented disparity in breast cancer death rates between whites and racial and ethnic minorities, such as African Americans, and the differential rates of decline in breast cancer mortality (2.4% per year in whites, 1.8% in Latino women, and 1.0% in African Americans).23,24 The shortage of minority women might result from a lack of concerted effort or ingenuity during recruitment or the unwillingness of women to participate because of skepticism or fatalism. While the reason is most likely multifactorial, an effort should be made to address the issues that have prevented inclusion of more minority women.

In a cross-sectional study conducted by Bickell and colleagues,25 despite similar rates of oncological consultation, minority women with early-stage breast cancer had double the risk of white women of not receiving adjuvant treatment. Given that SEGT did enhance adherence to chemotherapy and hormone therapy in the Melbourne trial,17 could the intervention be adapted to respond sensitively to culturally based beliefs about illness and health, the doctor-patient relationship, and treatment preferences? Might the induction of some shift in these beliefs lead to improved adherence? Our research group is currently exploring this possibility. Measures of health beliefs are included in assessing the outcome of SEGT and serve as more proximal indicators of adherence to anticancer treatments. More research is needed to test this hypothesis and to elucidate the mediators of this effect.

Conclusion

The issues that women with advanced breast cancer face on a daily basis are taxing on both a physical and emotional level. SEGT can provide these women with the support needed to successfully adjust to the diagnosis and to find comfort in facing the illness head on. Although it remains to be determined whether SEGT can indeed improve treatment adherence and outcome for underserved populations, strong evidence supports SEGT as an effective intervention in reducing traumatic stress symptoms and, in most cases, improving mood symptoms. Future research is still needed, however, to address the points raised herein, including the personality and attachment styles that may respond well and the impact of culturally determined health beliefs on minority women.

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  • Andrykowski MA, Manne SL.Are psychological interventions effective and accepted by cancer patients? I. Standards and levels of evidence. Ann Behav Med. 2006;32:93-97.
  • Classen C, Butler LD, Koopman C, et al. Supportiveexpressive group therapy and distress in patients with metastatic breast cancer. Arch Gen Psychiatry. 2001;58: 494-501.
References
1. Edwards AG, Hailey S, Maxwell M. Psychological interventions for women with metastatic breast cancer. Cochrane Database Syst Rev. 2004;(2):CD004253.
2. Spiegel D. Effects of psychotherapy on cancer survival. Nature Rev. 2002;2:383-389.
3. Watson M, Haviland JS, Greer S, et al. Influence of psychological response on survival in breast cancer: a population-based cohort study. Lancet. 1999;354:1331-1336.
4. Goodwin PJ, Leszcz M, Ennis M, et al. The effect of group psychosocial support on survival in metastatic breast cancer. N Engl J Med. 2001;345:1719-1726.
5. Kissane DW, Grabsch B, Clarke DM, et al. Supportive-expressive group therapy for women with metastatic breast cancer: survival and psychosocial outcome from a randomized controlled trial. Psychooncology. 2007; 16:227-286.
6. Spiegel D, Butler LD, Giese-Davis J, et al. Supportive expressive group therapy and survival in patients with metastatic breast cancer: a randomized clinical intervention.Presented at: the Annual Meeting of the American Psychiatric Association; May 20-25, 2006; Toronto.
7. Johansen C, Olsen JH. Psychological stress, occurrence of cancer and cause-specific mortality [in Danish]. Ugeskr Laeger. 1998;160:2699-2703.
8. Spiegel D, Classen C. Group Therapy for Cancer Patients: A Research-Based Handbook of Psychosocial Care. New York: Basic Books; 2006.
9. Kissane DW, Grabsch B, Clarke DM, et al. Supportive-expressive group therapy: the transformation of existential ambivalence into creative living while enhancing adherence to anti-cancer therapies. Psychooncology. 2004; 13:755-768.
10. Spiegel D, Bloom JR. Group therapy and hypnosis reduce metastatic breast carcinoma pain. Psychosom Med. 1983;45:333-339.
11. Spiegel D, Bloom JR, Yalom I. Group support for patients with metastatic cancer: a randomized prospective outcome study. Arch Gen Psychiatry. 1981;38:527-533.
12. Spiegel D, Bloom JR, Kraemer HC, Gottheil E. Effect of psychosocial treatment on survival of patients with metastatic breast cancer. Lancet. 1989;2:888-891.
13. Fox BH. A hypothesis about Spiegel et al's 1989 paper on psychosocial intervention and breast cancer survival. Psychooncology. 1998;7:361-370.
14. Goodwin PJ, Pritchard KI, Spiegel D. The fox guarding the clinical trial: internal versus external validity in randomized trials. Psychooncology. 1999;8:275.
15. Fox BH. Clarification regarding comments about a hypothesis. Psychooncology. 1999;8:366-367.
16. Classen C, Butler LD, Koopman C, et al. Supportive-expressive group therapy and distress in patients with metastatic breast cancer. Arch Gen Psychiatry. 2001;58: 494-501.
17. Kissane DW, Grabsch B, Clarke DM, et al. Supportive-expressive group therapy for women with metastatic breast cancer: survival and psychosocial outcome from a randomized controlled trial. Psychooncology. 2007;16: 277-286.
18. Giese-Davis J, Koopman C, Butler LD, et al. Change in emotion-regulation strategy for women with metastatic breast cancer following supportive-expressive group therapy. J Consult Clin Psychol. 2002;70:916-925.
19. Butler LD, Koopman C, Cordova MJ, et al. Psychological distress and pain significantly increase before death in metastatic breast cancer patients. Psychosom Med. 2003;65:416-426.
20. Goodwin PJ, Black JT, Bordeleau LJ, Ganz PA. Health-related quality-of-life measurement in randomized clinical trials in breast cancer: taking stock. J Natl Cancer Inst. 2003;95:263-281.
21. Andrykowski MA, Manne SL. Are psychological interventions effective and accepted by cancer patients? I. Standards and levels of evidence. Ann Behav Med. 2006;32:93-97.
22. Coyne JC, Lepore SJ, Palmer SC. Efficacy of psychosocial interventions in cancer care: evidence is weaker than it first looks. Ann Behav Med. 2006;32:104-110.
23. American Cancer Society: Breast Cancer Facts and Figures, 2005-2006. Atlanta: American Cancer Society, Inc.
24. Smigal C, Jemal A, Ward E, et al. Trends in breast cancer by race and ethnicity: update 2006. CA Cancer J Clin. 2006;56:168-183.
25. Bickell NA, Wang JJ, Oluwole S, et al. Missed opportunities: racial disparities in adjuvant breast cancer treatment. J Clin Oncol. 2006;24:1357-1362.


 
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