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The Role of Gender in Disease Expression: A Literature Review

The Role of Gender in Disease Expression: A Literature Review

Gender differences in obsessive-compulsive disorder: a literature review

de Mathis MA, de Alvarenga P, Funaro G, et al. Rev Bras Psiquiatr. 2011;33:390-399.

OCD is made up of heterogeneous subtypes—one such is gender, which plays a relevant role in phenotypic expression. In this literature review, the researchers looked at 63 studies to determine the gender differences in clinical, genetic, and familial aspects of OCD. They found that males were more likely to be sin-gle; to present with an early onset and chronic course; and to have greater social impairment, more sexual-religious and aggressive symptoms, and greater comorbidity with tic and substance use disorders. Females had more contamination/cleaning symptoms and greater comorbidity with eating and impulse control disorders. Although the studies are inconclusive, they suggest that gender plays a role in disease expression of OCD.

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