Answer: B. One-third
Up to one-third of depressed patients are resistant to treatment with conventional antidepressants. Major depression is a disease that affects approximately 20 million adults in the US and has a devastating impact on personal and public health.
Although successful treatment substantially reduces functional impairment and economic burden, many depressed people are resistant to treatment with medications (eg, serotonin and/or norepinephrine reuptake inhibitors). This is the case, even in the context of standardized attempts such as switching medications and/or augmenting with thyroid hormone, mood stabilizers, and atypical antipsychotics.
Roughly 7 million adults in the US are considered to have treatment-resistant depression (TRD), which emphasizes the need to develop new conceptual frameworks and new therapeutic targets to improve treatment outcome.
For more information, please see “Inflammation and Treatment Resistance in Major Depression,” by Charles L. Raison, MD, Jennifer C. Felger, PhD, and Andrew H. Miller, MD, on which this quiz was based.