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Major Depressive Disorder

The Implications of Chronobiology for Psychiatry

Chronobiology has undergone exponential growth in the past decade, with major discoveries at the molecular and neuroanatomic level.

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Cultural Disparities in Mental Health Care: Closing the Gap
Persistent Depressive Disorder

Major Depressive Disorder

What to do once treatment-resistant depression is established based on risk factors and exclusion of other conditions? Insights here—and a treatment algorithm.

The discovery that a single IV infusion of low-dose (subanesthetic) ketamine exerts rapid antidepressant effects constitutes an expansion in our understanding of the neurobiology of depression and provides new avenues for drug development.

Genius and madness: does one phenomenon cause the other -- or do both share a common underlying factor or mechanism? How are geniuses able to accomplish “creative fits”? The author explores both questions.

How can we get even better at customizing treatment for our patients and thereby achieve improved outcomes? How do we avoid becoming relegated to mere brokers of psychopharmacologic commodities? A few thoughts in this brief communication.

The lay press has focused a lot of attention on the use of ketamine as a potentially rapidly acting treatment for depression. But are psychiatrists really ready to offer ketamine as a treatment alternative for mood disorders? An expert weighs in.

Suicide is not being adequately addressed in terms of prevention, and part of that process is better education of mental health professionals and primary care physicians. More in this expert Q&A.

Standardized, quantifiable outcome measures exist for most major psychiatric disorders, yet they are rarely used in routine clinical practice. This article identifies the rationale for using psychiatric scales.

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