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Major Depressive Disorder

The Implications of Chronobiology for Psychiatry

Chronobiology has undergone exponential growth in the past decade, with major discoveries at the molecular and neuroanatomic level.

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Cultural Disparities in Mental Health Care: Closing the Gap
Persistent Depressive Disorder

Major Depressive Disorder

Patients with severe depression are more likely to have symptom remission with a combination of cognitive therapy and antidepressant medication than those with less severe or more chronic illness.

In this video, Dr Andrew Solomon talks about how psychiatrists and psychologists can help depressed or traumatized patients foster resilience, without trivializing their pain.

In what psychiatric disorder, if any, has wake therapy been useful to alleviate symptoms? Take the quiz and learn more.

Standardized, quantifiable outcome measures exist for most major psychiatric disorders, yet they are rarely used in routine clinical practice. This article identifies the rationale for using psychiatric scales.

What to do once treatment-resistant depression is established based on risk factors and exclusion of other conditions? Insights here—and a treatment algorithm.

The discovery that a single IV infusion of low-dose (subanesthetic) ketamine exerts rapid antidepressant effects constitutes an expansion in our understanding of the neurobiology of depression and provides new avenues for drug development.

Genius and madness: does one phenomenon cause the other—or do both share a common underlying factor or mechanism? How are geniuses able to accomplish “creative fits”? The author explores both questions.

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