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ADD: Is the "Epidemic" About to Get Worse?

By Allen Frances, MD | March 12, 2010

Our country is in the midst of a 15-year "epidemic" of Attention Deficit Disorder (ADD). There are 6 potential causes for the skyrocketting rates of ADD-- but only 5 have been real contributors. The most obvious explanation is by far the least likely -- that the prevalence of attention deficit problems in the general population has actually increased in the last 15 years. Human nature is remarkably constant and slow to change, while diagnostic fads come and go with great rapidity. We don't have more attention deficit than ever before. . . we just label more attentional problems as mental disorder.


The "epidemic" can be traced to a complex interaction among 5 other contributors:
1. Wording changes in DSM-IV (published in 1994)
2. Heavy drug company marketing to doctors and advertising to the general public
3. Extensive media coverage
4. Pressure from parents and schools to control unruly children
5. The use of stimulants for performance enhancement.

There is controversy on whether the resulting increased prevalence of ADD should be the cause of celebration or concern- -or perhaps both. Some believe that the higher rates mostly reflect the useful identification of ADD in patients who were previously missed. No doubt increased diagnosis has been helpful for many people who otherwise would not have received appropriate treatment with stimulus medication.


This gain has to be offset against the serious costs to many others. Some of the increased prevalence of ADD (no one can tell for sure what proportion) results from the "false positive" misidentification of people who would be better off never receiving a diagnosis. The rapid expansion of stimulant use has undoubtedly led to unnecessary treatment with medications that sometimes cause harmful side effects and complications. There is also a large problem with stimulant misuse for purposes of performance enhancement and abuse for purposes of intoxication- both leading to the development of a large, illegal secondary market for stimulant drugs.


DSM5 will become the official manual for psychiatric diagnosis when it is published in 2013. The recently posted first draft contains a number of suggestions that would make it even easier to get a diagnosis of ADD:

1. Raising the requirement that onset of symptoms occur before age 7 to age 12
2. Dramatically reducing the symptom threshold for adult ADD
3. Removing the requirement that there be accompanying clinically significant distress or impairment
4. Allowing the diagnosis of ADD in those who also have the diagnosis of autism.


In developing DSM-IV, we hoped to be careful and conservative. We believed that the diagnostic system should remain stable unless there was compelling evidence that change would be more helpful than harmful. We performed an extensive field trial that predicted (it turned out incorrectly) that our wording clarifications would not change the rates of ADD. Our experience proved that even small changes in the diagnostic criteria can have large unintended, and often unfortunate consequences.


The changes suggested for DSM5 are radical and could add fuel to the fire of the already raging "epidemic" of excessive diagnosis and treatment of ADD. I would suggest there be a careful risk/benefit analysis (that includes input from the public and consideration of public policy implications) before any of these changes are made official. Problems with attention and hyperactivity are very common in the general population. There is no clear boundary to determine when these can be considered as no more than normal variation and when they are best labeled and treated as a mental disorder. There are also many, many causes for distractability other than ADD. These include mood and anxiety problems, substance use, insomnia, stress, overextended scheduling, and many, many more.

 

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by Manuel Mota | March 13, 2010 12:54 AM EST

Dr. Frances:  Once again I have to thank you for lending your powerful and respected voice to a cause that I have been fighting for many years. Your commentary is so eloquent that nothing needs to be added except perhaps for a reflection I said today to a medical student:  "Can you imagine any specialist with a practice that shows a 90% prevalence of one disease?...for example, an oncologist who diagnoses 90% of  his or her patients with a meningioma. It would be a scandal but, for reasons that I don't know, in psychiatry nothing is said when thousands of my colleagues give an ADHD diagnosis to 8-9 out of every 10 patients they evaluate."

     Unfortunately, this situation is ignored by the APA and the AACAP despite the harm that amphetamines  would cause to a person with mania, anxiety or psychosis when prescribed for a wrong diagnosis of ADHD.   My fear is that by the time of their awakening to this reality it is going to be too late for those misdiagnosed patients.

Manuel Mota-Castillo, M.D.

 

by Vatsal Thakkar | April 14, 2010 3:54 PM EDT

I would like to be the dissenting voice.  I had a similar view of the adult ADHD diagnosis and prevalence while in residency and even for the first few years of practice.  Having been educated in its diagnosis and treatment for the last 4+ years, it is astonishing at the level of comorbid ADHD that I was missing:  Many patients who had relapsing substance abuse problems, treatment-resistant depression, and even bipolar disorder (where untreated ADHD can contribute to med noncompliance or worsened cognitive sxs with mood stabilizers) I have seen get significantly better if they had comorbid ADHD which was finally diagnosed and treated.

In addition, let's separate two issues:  the dx of ADHD and the prescription of stimulants.  Let's not castigate a diagnosis just because one of the treatments is a controlled substance.  Let's also remember that there are now 3 non-controlled Rx treatments for ADHD:  atomoxetine, guanfacine, and clonidine.  There are also a multitude of behavioral and lifestyle changes that are applicable. 

Sure, some are probably quick to diagnose.  However, with the plethora of robust pathophysiologic, neuroimaging, and genetics data supporting the prevalence of ADHD, and its response to treatment, it would be imprudent to dismiss the existence and prevalence of this diagnosis, especially in adults (4-5% prevalence), and especially in an adult psychiatric outpatient population (10-25% prevalence).

Vatsal G. Thakkar, M.D.
NYU School of Medicine






 
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