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TEST YOUR IMAGE IQ 

NSCLC Patient Develops Fever and Rash Following Treatment for Brain Metastases

By Ted Rosen, MD | July 30, 2012
Professor of Dermatology at Baylor College of Medicine; Chief of Dermatology at Michael E. DeBakey VA Medical Center

References

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3. Rowe JE, Pina J, Sau P, et al. Toxic epidermal necrolysis associated with diphenylhydantoin and cranial irradiation. Int J Dermatol. 1991;30:747-749.

4. Cockey GH, Amann ST, Reents SB, et al. Stevens-Johnson syndrome resulting from whole-brain irradiation and phenytoin. Am J Clin Oncol. 1996;19:32-34.

5. Khafaga YM, Jamshed A, Allam AA, et al. Stevens-Johnson syndrome in patients on phenytoin and cranial radiotherapy. Acta Oncol. 1999;38:111-116.

6. Micali G, Linthicum K, Han N, et al. Increased risk of erythema multiforme major with combination anticonvulsant and radiation therapies. Pharmacotherapy. 1999;19:223-227.

7. Eralp Y, Aydiner A, Tas F, et al. Stevens-Johnson syndrome in a patient receiving anticonvulsant therapy during cranial irradiation. Am J Clin Oncol. 2001;24:347-350.

8. Ahmed I, Reichenberg J, Lucas A, et al. Erythema multiforme associated with phenytoin and cranial radiation therapy: a report of three cases and review of the literature. Int J Dermatol. 2004;43:67-73

9. Aguiar D, Pazo R, Duran I, et al. Toxic epidermal necrolysis in patients receiving anticonvulsants and cranial irradiation: a risk to consider. J Neurooncol. 2004;66:345-350.

10. Wohrl S, Loewe R, Pickl WF, et al. EMPACT syndrome. J Dtsch Dermatol Ges. 2005;3:39-43.

11. Aydogan K, Vatansever S, Adim SB, et al. EMPACT syndrome: A case report and review of the literature. Int J Dermatol. 2010;49:945-949.

12. Bilgili SG, Calka O, Karadag AS, et al. EMPACT syndrome. Cutan Ocul Toxicol. 2011;30:328-330.

13. Haruda F. Phenytoin hypersensitivity: 38 cases. Neurology. 1979;29:1480-1485.

14. Strom J. Aetiology of febrile mucocutaneous syndromes with special reference to the provocative role of infections and drugs. Acta Med Sci. 1977;201:131-136.

15. Mamon HJ, Wen PY, Burns AC, et al. Allergic skin reactions to anticonvulsant medications in patients receiving cranial irradiation. Epilepsia. 1999;40:341-344.

16. Zeng YD, Zhang L, Liao H, et al. Gefitinib alone or with concomitant whole brain radiation therapy for patients with brain metastasis from non-small cell lung cancer: A retrospective study. Asian Pac J Cancer Prev. 2012;13:909-914.

17. Villaneuva V, Codina M, Elices. Management of epilepsy in oncological patients. Neurologist. 2008;4(6Suppl1):S44-S54.

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