Obsessive-compulsive disorder (OCD) is a heterogeneous disorder with a variety of phenotypic expressions. Delineation of clinically distinct subtypes of the disorder may be valuable in predicting treatment response and resistance. More>>

DURHAM, N.C. -- The mystery of obsessive-compulsive disorder may be at least partly solved, with a discovery that implicates a structural protein missing in the brains of certain excessively groomed mice. More>>

DURHAM, N.C. -- The mystery of obsessive-compulsive disorder may be at least partly solved, with a discovery that implicates a structural protein missing in the brains of certain excessively groomed mice. More>>

Patients with OCD generally respond best to cognitive-behavioral therapy (CBT). At the core of the behavior therapy program is a technique known as exposure and ritual prevention (ERP). More>>

Obsessive-compulsive disorder is a prevalent, disabling and chronic illness. Serotonin reuptake inhibitors are the first-line of treatment; however a large proportion of patients will have either a partial or nonresponse. This review outlines the strategies for treatment-resistant OCD, including augmentation agents, alternative monotherapies, intravenous strategies and newer nonpharmacologic somatic treatments under development. More>>