(AAOS2015) Total knee replacements appear successful for the relatively young and active as well as for those over 90. For people with the most preoperative pain, however, they may not help at all.

(AAOS2015) The first study to assess the effect of steroid injections on the hip joint suggests that they may hasten joint degeneration, but the co-injected local anesthetic is also suspect.

Pfizer and Lilly will resume development of the anti-nerve growth factor monoclonal antibody tanezumab for osteoarthritis pain, after the FDA lifted its ban imposed due to adverse effects in animal trials.

The good news: At best, intraarticular hyaluronate injected into the knee for osteoarthritis (OA) is modestly effective. The bad news: At worst, it’s indistinguishable from placebo, in some meta-analyses.

knee osteoarthritis

An article describes attractive reasons to defer knee replacement. Researchers are working to find ways to replace damaged cartilage and collagen, and promote healing within the joint.

Norman B. Gaylis MD

A Miami rheumatologist tells why he has donated $1 million to offer his colleagues in community practice the chance to pursue their own clinical theories.


A comprehensive review covers current understanding of the mechanisms of osteoarthritis, including histology and signaling pathways, and options for early intervention and prevention of progression.


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