July 2006, Vol. XXIII, No. 8
Avoidant personality disorder (APD) is characterized by a general tendency to fear and avoid social interactionseven interactions with persons who are well known to the individual. In addition to deserving our clinical and research attention in its own right, APD highlights some of the key controversies with our current classification system. These debates include the "horizontal" boundaries between different Axis I and Axis II conditions as well as the "vertical" boundaries between a clinical disorder and certain personality or temperamental traits. In pediatric psychiatry, use of the diagnosis underscores the conflict between the motivation to avoid Axis II diagnoses in children and adolescents and the motivation toward early identification and early intervention of psychiatric illness.
In this article, I will briefly summarize some of the key components of APD, with a focus on epidemiology, assessment, diagnostic dilemmas, and treatment.
Background and epidemiology
DSM-IV defines APD as "a pervasive pattern of social inhibition, feelings of inadequacy, and hypersensitivity to negative evaluation that begins by early adulthood and is present in a variety of contexts." In persons with APD, the avoidance of, and restraint during, social contact is the result of fears of rejection and humiliation.
APD is one of the cluster C personality disorders, along with dependent and obsessive-compulsive personality disorders. The level of impairment associated with APD is high; employment, interpersonal relationships, and global functioning are all negatively affected. The morbidity associated with APD rivals and even exceeds that associated with such Axis I disorders as major depressive disorder.1
APD is relatively common; the prevalence is about 5% in the community2 and nearly 15% among psychiatric outpatients.3 As such, APD is one of the mostif not the mostprevalent personality disorders. APD occurs about equally between males and females.
The symptoms of APD often appear early and the disorder can be distinguished from other personality disorders by elementary school or even earlier. Adults with APD reported less involvement in extracurricular activities and sports, and were less popular than adults with another personality disorder or major depression.4 Kagan5 and Hirshfeld and colleagues6 have characterized a temperamental trait labeled behavioral inhibition that applies to children who have a strong tendency to be shy and restrained in novel situations. Behavioral inhibitiona potential precursor to later social anxiety and avoidancehas been reliably assessed in children 2 years old and perhaps even younger.5,7
Longitudinal research has demonstrated detectable, although certainly not inevitable, links between behavioral inhibition and many disorders in childhood and adolescence. These include social anxiety disorder and avoidant disorder (as defined in DSM-III-R).7,8 Emotional disorders, such as anxiety, depression, and eating disorders, in adolescence predict cluster C personality disorders in adulthood in women.9
While there appears to be at least some continuity between adult APD and childhood symptoms, accumulating research is beginning to demonstrate a more waxing and waning course of APD symptoms through adulthood than had originally been expected. A 2-year prospective study from the Collaborative Longitudinal Personality Disorders Study found that over time, feelings of inadequacy and social ineptness and the need to be certain of being liked before entering into social situations were more stable than worries about shame and risks of exposure in one's employment.10
Considerably less is known about APD as affected persons age. The disorder is scarcely studied in geriatric psychiatry.
Diagnosis in children and adolescents
The finding in APD and other personality disorders that there is an onset of symptoms in childhood and adolescence represents a dilemma for many clinicians. On one hand, our training dictates the general principal of early identification and intervention to help avoid or reduce long-term suffering. At the same time, clinicians tend to avoid diagnosing personality disorders in children and adolescents.11 While the reasons for this practice are not entirely clear, the tendency may be based in part on the notion that a child's personality is still "in progress" and thus he or she should not be labeled as "disordered" for fear of stigmatization.
While this concept has some merit, it is also flawed. Symptoms of Axis I disorders, such as attention-deficit/hyperactivity disorder, also tend to undergo change through the course of the person's development, yet this does not prevent clinicians from making a diagnosis at a particular point to allow for the amelioration of impairing symptoms.
Furthermore, personality development does not stop when a patient reaches age 18. As for stigmatization, it is not intuitively obvious why a diagnosis of APD carries a higher burden than many other conditions that can be diagnosed before adulthood, such as social anxiety disorder.
A final obstacle to diagnosing APD in children is the criterion that a cause for social avoidance be identified (eg, fear or shame or embarrassment). Such a cause may be difficult to detect in younger children, whose self-consciousness is still developing.
Etiology and neurobiology
There has been little research into the cause and pathophysiology of APD per se, although much literature exists about related Axis I conditions or traits, such as shyness. Behavioral inhibition and other temperament traits like it (eg, harm avoidance) are thought to be related to overactivity of regions of the brain that are involved in the fear response. One recent study found evidence that high levels of harm avoidance were related to decreased coupling between the amygdala and the anterior cingulate gyrus which, in turn, may be related to genes involved in serotonin transmission.12
The heritability of behavioral inhibition ranges from 25% to 44%, as measured in toddlers.13 Interestingly, there is some evidence to support stronger genetic associations with the personality dimensions that may underlie APD than with the specific APD symptoms themselves.14