Dr Hensley reports that she is on the Speakers' Bureau for Forest Laboratories and has received research grant support from Forest and Pfizer. Dr Clayton reports that she is on the Speakers' Bureau for Forest.



1. US Census Bureau. Time series of estimated national demographic components of change: July 1, 2000 to July 1, 2001. Population Division, US Census Bureau. December 27, 2001. http://www.census.gov/popest/archives/2000s/vintage_2001/US- 2001EST-03.pdf. Accessed June 5, 2008.
2. Shear K, Frank E, Houck PR, Reynolds CF 3rd. Treatment of complicated grief: a randomized controlled trial. JAMA. 2005;293:2601-2608.
3. LaRue A, Dessonville C, Jarvik LF. Aging and mental disorders. In: Birren JE, Schaie KW, eds. Handbook of the Psychology of Aging. 2nd ed. New York: Van Nostrand Reinhold; 1985:664-702.
4. Clayton PJ. Bereavement. In: Paykel ES, ed. Handbook of Affective Disorders. New York: Guilford Press; 1982:403-415.
5. Bonanno GA, Kaltman S. The varieties of grief experience. Clin Psychol Rev. 2001;21:705-734.
6. Clayton PJ. Bereavement and depression. J Clin Psychiatry. 1990;51(suppl):34-40.
7. Clayton PJ, Darvish HS. Course of depressive symptoms following the stress of bereavement. In: Barrett J, Rose RM, Klerman GL, eds. Stress and Mental Disorder. New York: Raven Press; 1979:121-136.
8. Zisook S, Kendler KS. Is bereavement-related depression different than non-bereavement-related depression? Psychol Med. 2007;37:779-794.
9. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed, text rev. Washington, DC: American Psychiatric Publishing; 2000.
10. Zisook S, Shuchter SR. Depression through the first year after the death of a spouse. Am J Psychiatry. 1991;148:1346-1352.
11. Zisook S, Shuchter SR, Sledge PA, et al. The spectrum of depressive phenomena after spousal bereavement. J Clin Psychiatry. 1994;55(suppl):29-36.
12. Steffens DC, Skoog I, Norton MC, et al. Prevalence of depression and its treatment in an elderly population: the Cache County study. Arch Gen Psychiatry. 2000;57:601-607.
13. Turvey CL, Carney C, Arndt S, et al. Conjugal loss and syndromal depression in a sample of elders aged 70 years or older. Am J Psychiatry. 1999;156:1596-1601.
14. Zisook S, Shuchter SR. Major depression associated with widowhood. Am J Geriatr Psychiatry. 1993; 1:316-326.
15. Stroebe M, Schut H, Stroebe W. Health outcomes of bereavement. Lancet. 2007;370:1960-1973.
16. Wehr TA. Sleep-loss as a possible mediator of diverse causes of mania. Br J Psychiatry. 1991;159: 576-578.
17. Wehr TA. Improvement of depression and triggering of mania by sleep deprivation. JAMA. 1992;267:548-551.
18. Columbo C, Benedetti F, Barbini B, et al. Rate of switch from depression into mania after therapeutic sleep deprivation in bipolar depression. Psychiatry Res. 1999;86:267-270.
19. Husaini BA, Cummings S, Kilbourne B, et al. Group therapy for depressed elderly women. Int J Group Psychother. 2004;54:295-319.
20. Allumbaugh DL, Hoyt WT. Effectiveness of grief therapy: a meta-analysis. J Couns Psychol. 1999;46: 370-380.
21. Jordan JR, Neimeyer RA. Does grief counseling work? Death Stud. 2003;27:765-786.
22. Forte AL, Hill M, Pazder R, et al. Bereavement care interventions: a systematic review. BMC Palliative Care. 2004;3:3. http://www.biomedcentral.com/1472-684X/3/3. Accessed June 5, 2008.
23. Jacobs SC, Nelson JC, Zisook S. Treating depressions of bereavement with antidepressants. A pilot study. Psychiatr Clin North Am. 1987;10:501-510.
24. Pasternak RE, Reynolds CF 3rd, Schlernitzauer M, et al. Acute open-label trial of nortriptyline therapy of bereavement-related depression in late life. J Clin Psychiatry. 1991;52:307-310.
25. Zisook S, Shuchter SR, Pedrelli P, et al. Bupropion sustained release for bereavement: results of an open trial. J Clin Psychiatry. 2001;62:227-230.
26. Oakley F, Khin NA, Parks R, et al. Improvements in activities of daily living in elderly following treatment for post-bereavement depression. Acta Psychiatr Scand. 2002;105:231-234.
27. Warner J, Metcalfe C, King M. Evaluating the use of benzodiazepines following recent bereavement. Br J Psychiatry. 2001;178:36-41.
28. Reynolds CF 3rd, Miller MD, Pasternak RE, et al. Treatment of bereavement-related major depressive episodes in later life: a controlled study of acute and continuation treatment with nortriptyline and interpersonal psychotherapy. Am J Psychiatry. 1999;156: 202-208.
29. Zygmont M, Prigerson HG, Houck PR, et al. A post hoc comparison of paroxetine and nortriptyline for symptoms of traumatic grief. J Clin Psychiatry. 1998; 59:241-245.
30. Simon NM, Thompson EH, Pollack MH, et al. Complicated grief: a case series using escitalopram. Am J Psychiatry. 2007;164:1760-1761.