• A meta-analysis found a significant association between schizophrenia and infection by Human Herpesvirus 2 (OR=1.34; CI 95%: 1.09–1.70), Borna Disease Virus (OR=2.03; CI 95%: 1.35–3.06), Human Endogenous Retrovirus W (OR=19.31; CI 95%: 6.74–55.29), Chlamydophila pneumoniae (OR=6.34; CI 95%: 2.83–14.19), Chlamydophila psittaci (OR=29.05; CI 95%: 8.91–94.70) and Toxoplasma gondii (OR=2.70; CI 95%: 1.34–4.42).
• By contrast, there was not a significant association between risk of schizophrenia and exposure to Epstein-Barr virus, human herpesvirus (HHV)-1, HHV-2, HHV-6, varicella zoster virus, or cytomegalovirus
• The observation that a myriad of different infectious agents—bacteria, viruses, and protozoans—are association with schizophrenia risk raises the possibility that that the immune response to infection may play a role.
Arias I, Sorlozano A, Villegas E, de Dios Luna J, McKenney K, Cervilla J, Gutierrez B, Gutierrez J. Infectious agents associated with schizophrenia: a meta-analysis. Schizophr Res. 2012;136:128-36.