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Pesticide Tied to Sleep Problem (CME/CE)
www.medpagetoday.com - 6/26/12
Medical News: SLEEP: Melatonin Improves REM-sleep Behavior Disorder
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PATIENT RESOURCES
What Makes You Sleep?
www.nhlbi.nih.gov - 10/2/13
What Is Narcolepsy?
www.nhlbi.nih.gov - 3/21/13
What Are Sleep Deprivation and Deficiency?
www.nhlbi.nih.gov - 3/20/13
 
CLINICAL TRIALS
Single Dose Pharmacokinetic and Pharmacodynamic Evaluation of Three Different Doses of Zolpidem in Children
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Sleep Disorders of Patients With Diseases of the Nervous System
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Quetiapine for the Treatment of Insomnia in Alzheimer's Disease
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REM Sleep Parasomnias

 
 
LATEST FEATURES
April 24, 2013
Sleep Disorders Resource for Primary Care Physicians
Sleep disorders are among the most common medical complaints. To better address the problem, the NSF has launched a comprehensive free online sleep... More »
October 4, 2012
Might Obstructive Sleep Apnea Explain Your Patient's Nightmares?
Consider OSA in your the differential diagnosis in patients who present with nightmarers. Continuous positive airway pressure (CPAP) can provide... More »
June 18, 2007
APSS: A Dead Body Climbed on Top of Me: Details on Sleep Paralysis
MINNEAPOLIS -- Sleep paralysis is common among Mexican adolescents, researchers reported here. More »
June 18, 2007
APSS: A Dead Body Climbed on Top of Me: Details on Sleep Paralysis
MINNEAPOLIS -- Sleep paralysis is common among Mexican adolescents, researchers reported here. More »
May 1, 2007
Perceptions
The Science of Sleep. A quirky Indy motion picture by that title was in theaters last year. The plot concerned an odd but wildly creative and... More »
October 1, 2006
Assessment and Management of Sleep Disorders in Children
Sleep disorders are very common and are often underrecognized and underreported in children. If left untreated, these disorders can cause serious... More »
Showing 1 - 6 of 10 results.
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JOURNAL SCAN
Adult Onset Autosomal Dominant Leukodystrophy Presenting with REM Sleep Behavior Disorder (P05.021)
www.neurology.org - 2/13/13

OBJECTIVE: To report a case of Adult-Onset Autosomal Dominant Leukodystrophy (ADLD) presenting with Rapid Eye Movement (REM) sleep behavior disorder (RBD).

BACKGROUND: ADLD is a slowly progressive hereditary disease of the white matter caused by duplication of the nuclear lamina protein Lamin B1 on Chromosome 5q23.2. Patients usually present in the 4th – 5th decade with autonomic symptoms followed by pyramidal and cerebellar dysfunction. RBD is a parasomn

Detecting Dopaminergic Deficits in Individuals at Risk for Parkinsonism (IN2-1.006)
www.neurology.org - 2/13/13

OBJECTIVE: To demonstrate the presence of structural/functional or neurochemical changes or/and clinical features in a population of individuals at risk for developing Parkinson's disease. Specifically this study focuses on idiopathic REM sleep disorder (iRBD; N=15) and those with heterozygous or homozygous mutations in Gaucher disease (GBA; N=10) as they compare to individuals with Parkinsons disease (PD; N=15) and age-matched controls (N=15).

BACKGROUND: Individuals with iRBD and

BMC Neurology | Full text | Probable rapid eye movement sleep behavior disorder, nocturnal disturbances and quality of life in patients with Parkinsons disease: a case-controlled study using the rapid eye movement sleep behavior disorder screening questi
www.biomedcentral.com - 2/8/13
Increasing evidence provides a clear association between rapid eye movement sleep behavior disorders (RBD) and Parkinsons disease (PD), but the clinical features that determine the co-morbidity of RBD and PD are not yet fully understood.|Increasing evidence provides a clear association between rapid eye movement sleep behavior disorders (RBD) and Parkinsons disease (PD), but the clinical features that determine the co-morbidity of RBD and PD are not yet fully understood.
Adult-onset autosomal dominant leukodystrophy presenting with REM sleep behavior disorder
www.neurology.org - 12/23/12

Adult-onset autosomal dominant leukodystrophy (ADLD) is a slowly progressive hereditary disease of the white matter caused by duplication of the nuclear lamina protein lamin B1 on chromosome 5q23.2.1 Patients usually present in the 4th–5th decade with autonomic symptoms followed by pyramidal and cerebellar dysfunction.2 In ADLD, MRI head reveals symmetric T2-signal hyperintensities in the subcortical white matter, brainstem, and middle cerebellar peduncles.2 REM

Environmental risk factors for REM sleep behavior disorder: A multicenter case-control study
www.neurology.org - 7/29/12
Objective:

Idiopathic REM sleep behavior disorder is a parasomnia characterized by dream enactment and is commonly a prediagnostic sign of parkinsonism and dementia. Since risk factors have not been defined, we initiated a multicenter case-control study to assess environmental and lifestyle risk factors for REM sleep behavior disorder.

 Methods:

Cases were patients with idiopathic REM sleep behavior disorder who were free of dementia and parkinsonism, recruited

 
MEDLINE
Diagnostic tools for REM sleep behavior disorder.
pubmed.gov - 9/30/12
Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by loss of muscle atonia during REM sleep that results in motor behaviors. Diagnosis of RBD involves a clinical interview in which history of dream enactment behaviors is elicited and a subsequent overnight polysomnography (PSG) evaluation to assess for REM sleep without atonia (RWA) and/or observe motor behaviors during REM sleep. Therefore, the nature of RBD diagnosis involves both subjective and objective measurements that attempt to qualify and quantify the different diagnostic sub-criteria.|The primary aim of the current study was to identify and summarize the available clinical measurements that have been used for RBD assessment.|Two major online databases (MEDLINE and PsycInfo) were searched for articles developing, validating, or evaluating psychometric properties of the RBD diagnostic criteria or methods used for diagnosis. Studies of adult subjects (18 years or more) that included sufficient
Differential diagnoses of nocturnal fear and movement paroxysm: a case report.
pubmed.gov - 8/31/12
Recurrent nocturnal behavioural and movement paroxysms are a diagnostic challenge for the clinical pediatrician. We report on an adolescent girl who presents recurrent stereotypical nightmare-like episodes occurring during non-REM sleep stages 1-2 (N1 and N2). We discuss the differential diagnoses between epileptic and nonepileptic events and between nocturnal frontal and temporal seizures. The pathophysiological and unusual electroencephalographical features are discussed with respect to clinical features and results of interictal FDG-PET. Conclusion In case of stereotypical nightmare-like episodes in children or adolescents, an epileptic origin has to be ruled out before a parasomnia is diagnosed. In addition, a normal awake EEG or interictal sleep EEG in the diagnostic workup may not exclude an epileptic disorder. In case of nightly stereotypic motor or affective events, an epileptic disorder should be discussed.
Environmental risk factors for REM sleep behavior disorder: a multicenter case-control study.
pubmed.gov - 7/30/12
Idiopathic REM sleep behavior disorder is a parasomnia characterized by dream enactment and is commonly a prediagnostic sign of parkinsonism and dementia. Since risk factors have not been defined, we initiated a multicenter case-control study to assess environmental and lifestyle risk factors for REM sleep behavior disorder.|Cases were patients with idiopathic REM sleep behavior disorder who were free of dementia and parkinsonism, recruited from 13 International REM Sleep Behavior Disorder Study Group centers. Controls were matched according to age and sex. Potential environmental and lifestyle risk factors were assessed via standardized questionnaire. Unconditional logistic regression adjusting for age, sex, and center was conducted to investigate the environmental factors.|A total of 694 participants (347 patients, 347 controls) were recruited. Among cases, mean age was 67.7 9.6 years and 81.0% were male. Cases were more likely to smoke (ever smokers = 64.0% vs 55.5%, adjusted
REM sleep behavior disorder: from dreams to neurodegeneration.
pubmed.gov - 6/1/12
REM sleep behavior disorder is a unique parasomnia characterized by dream enactment behavior during REM sleep. Unless triggered by pharmacologic agents such as antidepressants, it is generally related to damage of pontomedullary brainstem structures. Idiopathic REM sleep behavior disorder (RBD) is a well-established risk factor for neurodegenerative disease. Prospective studies have estimated that at least 40-65% of patients with idiopathic RBD will eventually develop a defined neurodegenerative phenotype, almost always a 'synucleinopathy' (Parkinson's disease, Lewy Body dementia or multiple system atrophy). In most cases, patients appear to develop a syndrome with overlapping features of both Parkinson's disease and Lewy body dementia. The interval between RBD onset and disease onset averages 10-15 years, suggesting a promisingly large window for intervention into preclinical disease stages. The ability of RBD to predict disease has major implications for design and development of
A single-question screen for rapid eye movement sleep behavior disorder: a multicenter validation study.
pubmed.gov - 6/1/12
Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia that is an important risk factor for Parkinson's disease (PD) and Lewy body dementia. Its prevalence is unknown. One barrier to determining prevalence is that current screening tools are too long for large-scale epidemiologic surveys. Therefore, we designed the REM Sleep Behavior Disorder Single-Question Screen (RBD1Q), a screening question for dream enactment with a simple yes/no response.|Four hundred and eighty-four sleep-clinic-based participants (242 idiopathic RBD patients and 242 controls) completed the screen during a multicenter case-control study. All participants underwent a polysomnogram to define gold-standard diagnosis according to standard criteria.|We found a sensitivity of 93.8% and a specificity of 87.2%. Sensitivity and specificity were similar in healthy volunteers, compared to controls or patients with other sleep diagnoses.|A single-question screen for RBD may reliably detect disease



 
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