Restless Legs Syndrome

Her medical history includes hypertension, restless legs syndrome, bilateral knee replacements, and anxiety.

Ms J's medical history is notable for mild depression, Raynaud syndrome, and myelodysplasia/myelofibrosis. ... The clinical disorder or syndrome of insomnia ( Box 1) additionally specifies adequate opportunity and circumstances for sleep and significant

Restless legs syndrome (RLS) is a common sensorimotor disorder.(1) The symptoms have a strong circadian rhythmicity and are most severe at night and at rest. In the most severe cases, symptoms are accompanied by serious sleep disturbances and unbearable paresthesias. First-line treatments of RLS are dopamine agonists, but GABAergic anticonvulsants and opioids are also effective.(2,3) Patients with the most severe RLS are often treated with oral opioids.(4) The use of these may, however, be limited due to side effects. The intrathecal administration of opioids results in better pain relief and fewer side effects in severe chronic pain. Case reports of 4 patients have documented excellent results with short-term use of intrathecal opioids also in RLS.

Pathophysiology of restless legs syndrome is poorly understood. A role of the thalamus, specifically of its medial portion which is a part of the limbic system, was suggested by functional magnetic resonance imaging and positron emission tomography studies. The aim of this study was to evaluate medial thalamus metabolism and structural integrity in patients with idiopathic restless legs syndrome using a multimodal magnetic resonance approach, including proton magnetic resonance spectroscopy, diffusion tensor imaging, voxel-based morphometry and volumetric and shape analysis. Twenty-three patients and 19 healthy controls were studied in a 1.5T system. Single voxel proton magnetic resonance spectra were acquired in the medial region of the thalamus. In diffusion tensor examination, mean diffusivity and fractional anisotropy were determined at the level of medial thalamus using regions of interest delineated to outline the same parenchyma studied by spectroscopy. Voxel-based

Phenobarbital has been in clinical use as an antiepileptic drug (AED) since 1912. The initial clinical success of phenobarbital and other barbiturates affected the design of subsequent AEDs (e.g., phenytoin, primidone, ethosuximide), developed between 1938 and 1962, the chemical structures of which resemble that of phenobarbital. However, the empirical discovery of carbamazepine (1962) and the serendipitous discovery of valproic acid (1967) led to subsequent AEDs having chemical structures that are diverse and completely different from that of phenobarbital. Sixteen AEDs were introduced between 1990 and 2012. Most of these AEDs were developed empirically, using mechanism-unbiased anticonvulsant animal models. The empirical nature of the discovery of these AEDs, coupled with their multiple mechanisms of action, explains their diverse chemical structures. The antiepileptic market is therefore crowded. Future design of new AEDs must have a potential for treating nonepileptic central

The existence of an association between migraine and restless legs syndrome (RLS) has recently been reported, although the possible implications of this for migraine clinical presentation remain poorly understood. The objectives of this study were to determine RLS frequency in a population of migraineurs compared with healthy subjects and to assess RLS occurrence in episodic versus chronic migraine patients; the relationship between migraine-related disability and RLS comorbidity was also evaluated. Two hundred and seventy-seven consecutive migraineurs (ICHD-II, 2004) were enrolled and compared with 200 controls; migraine was episodic in 175 and chronic in 102 patients. RLS (IRLSSG criteria, 2003) was present in 22.7% of the total sample of migraineurs and in 7.5% of the controls (p<0.0001). RLS occurred significantly more frequently in chronic compared with episodic migraineurs (34.3% vs 16%, respectively, p=0.0006); a significant association between RLS diagnosis and moderate-severe

Restless legs syndrome (RLS) itself as well as the problems that are secondary to RLS may worsen the quality of life.|The aim of this study is to translate and validate the Restless Legs Syndrome Quality of Life (RLS-QOL) questionnaire in Hindi language. Settings and Designs: Patients attending psychiatry OPD and sleep clinic in a tertiary care teaching hospital.|Thirty four consecutive patients of RLS and twenty nine control subjects were included in the study. Permission for translation and validation of RLS-QOL questionnaire scale was obtained. Translation was done according to the guidelines provided by the publisher. After translation, the final version of the scale was applied in both the groups to find the reliability and validity.|SPSS, version 17.0 was used for the analysis. Independent sample t test was used to compare age. Chi-square test was applied to compare non-parametric variables. Pearson's and Spearman's correlations were used to find out the correlation between

Contains NHLBI clinical guidelines on Restless Legs Syndrome.

The treatment of restless legs syndrome and periodic limb movement disorder in adultsan update for 2012: practice parameters with an evidence-based systematic review and meta-analyses.

00-3788 Archive for historical Reference Only. 2MEMBERS OF THE NATIONAL HEART, LUNG, AND BLOOD INSTITUTE WORKING GROUP ON RESTLESS LEGS SYNDROME Michael Thorpy, M.D. ( ... 6Archive for historical Reference Only. 7RESTLESS LEGS SYNDROME DETECTION AND