Sleep Medicine Pharmacological Therapy Risks and Rewards

By Leo Robert | December 12, 2012

Given the high prevalence of sleep complaints in the general population and in patients with comorbid conditions, the pharmacological treatment options for sleep disorders are common and important considerations for both sleep specialists and nonspecialists, according to authors from the Sleep Division, Neurology Department, at Massachusetts General Hospital in Boston. In a comprehensive review article¹ that appeared in ISRN Pharmacology, they noted that recognizing the distribution of adverse effects, drug interaction profiles, metabolism, and cytochrome substrate activity may help clinicians address sleep issues more effectively.

The authors reviewed the pharmacological armamentarium in sleep medicine to provide a framework for risk-benefit considerations in clinical practice. Tables described sleeping pill; stimulant; and miscellaneous sleep medication characteristics, as well as significant contraindications. Figures outlined neuropsychiatric, cardiovascular, endocrine/metabolic, GI and genitourinary, and cytochrome P450 (CYP) profiles.

Key points in the review include the following:

• Clinical pharmacology in sleep medicine may be classified loosely as drugs aimed at managing sleepiness, sleeplessness, or sleep-related movements.

• When a patient presents reporting sleepiness, investigating potential primary causes, such as sleep apnea and insomnia, is critical.

• Pain syndromes, mood disorders, and general medical problems may be comorbid with sleep apnea or disrupted sleep, but residual daytime symptoms persist in some patients in spite of optimized management of potential primary causes, leading to consideration of stimulants in appropriate clinical settings.

• Insomnia may be considered a constellation of symptoms with a variety of underlying causes. A poorly understood aspect of insomnia is the misperception phenotype, in which patients underestimate their sleep times compared with objective measurements. The primary challenge in the diagnosis and management of insomnia is that both are based entirely on the clinical history and not on objective testing.

• Restless leg syndrome (RLS) and periodic limb movements of sleep are the most common movement disorders that result in sleep disturbance. They are managed similarly, often beginning with interrogation of iron stores and oral repletion, followed by dopaminergic medications. Pramipexole and ropinirole were developed for managing Parkinson disease but have been shown to improve RLS symptoms.

• The CYP family of heme-containing enzymes is involved in the metabolism of endogenous and exogenous organic molecules. The main contexts for considering the CYPs in clinical pharmacology are the effect of certain drugs on enhancing or inhibiting the action of one or more CYP enzymes and the increasing recognition that genetic polymorphisms may alter a patient’s metabolism of certain drugs.

References

1. Proctor A, Bianchi MT. Clinical pharmacology in sleep medicine. ISRN Pharmacol. 2012;2012:914168.

by Chagai Dubrawsky | December 13, 2012 6:53 PM EST

To fall asleep,one must drop its blood pressure by 10-15 mmHg. This is known as DIP.If you don't DIP,you Don't
sleep,period!This is a known fact that nobody should forget.
To wake up,one has to raise its blood pressure.This is written all over.
If you did not DIP your B.P.(None-Dipper),when you wake up your blood pressure may be dangerously high.
This stage of waking up is named:The Morning Surge(In hypertension).This is the 4 o'clock in the morning,when people present with heart attack,stroke OR they are just found dead in bed:"The Dead Man in The Bed " Syndrome.
Most of the Hypnotics do not DIP B.P.,Niacin does.

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