Is there a biomarker to predict response to treatment for depression?
The correct answer is D.
While high c-reactive protein (CRP) has predicted a poor response to some antidepressants, this is not a consistent finding, and elevations of this protein have preceded a good response to anti-inflammatory treatment.
Similarly, while a few attempts at multimodal models have been made and occasionally have had prospective validity, these have not been strong enough predictors or reliable across multiple studies. The same pattern of findings has occurred for a range of biological and non-biological markers.
However, as 50% of patients or fewer respond to available treatments, then prescriptive predictors are urgently needed to assist clinicians with selecting the optimal intervention from the wide range at our disposal.
For more on this topic, see Multimodal Markers and Biomarkers of Treatment, on which this quiz is based.