This AIDS-specialist offers his rank-order list of the top 10 HIV clinical trials that really made a difference. The trials differ substantially in design, size, and focus, but they all were “game changers.”
Younger antiretroviral therapy enrollees differ from older ones in demographic and clinical characteristics and are at higher risk for loss to follow-up. But interventions could reduce mortality and incidence.
Immune reconstitution inflammatory syndrome is seen in some HIV-infected patients soon after initiation of antiretroviral therapy. The syndrome can "unmask" dormant opportunistic infections or aggravate existing infections.