Major Depressive Disorder
Major Depressive Disorder
Demographic shifts and rising life expectancies will lead to an epidemic of chronic neuropsychiatric disease, and societal and public health costs will be enormous. Deep brain stimulation--a procedure that interfaces directly with the neural elements that drive pathological behavior--could be useful.
Mood switching is not uncommon and it is much more prevalent in depressed juveniles than in depressed adults, and there is a large apparent excess of antidepressant-associated switching over reported spontaneous diagnostic changes to bipolar disorder. Details here.
This article explores the current state of knowledge regarding personalized medicine in psychiatry and discusses how the tools might be used to help psychiatrists understand the components of their patients’ unique endophenotypic profiles.
There have been considerable advances in the research on and clinical use of neurostimulation for psychiatric disorders, especially mood disorders and MDD. Three of the most recognized are reviewed here. An experimental new treatment—- trigeminal nerve stimulation—- is also briefly discussed.
Learning to talk openly with patients about their suicidal ruminations poses more of an emotional than intellectual challenge.
In a PsychCongress presentation on perinatal mood disorders, Marlene Freeman, MD, stressed that treatment is essential for women with mood disorders—but whether to treat becomes complicated during a women’s reproductive years.
It is hard for mental health professionals to discuss completed suicides. Legal fears, confidentiality concerns, shame, and stigma are formidable obstacles. But talk we must, for talking—and listening—is a key to prevention and treatment.
Discussing the Neuropsychiatric Outcomes After Heart Surgery study, testing the vascular hypothesis of post-coronary artery bypass graft depression.
Mindfulness training is a viable treatment tool that rivals psychopharmaceutical agents for the treatment of addiction, anxiety, depression, and other psychiatric disorders.
The psychiatric aftermath of critical illness can involve emerging from the ICU with horrifying memories (of being tortured, raped, assaulted, or imprisoned).
The demands on physicians keep growing—they are not only responsible for assessment, diagnosis, and treatment, they are subject to all manner of related administrative and practice responsibilities. Not surprisingly, physicians are susceptible to burnout.
Can methylfolate play a role in the adjunctive treatment of patients with major depression? In this podcast, Rakesh Jain, MD, offers insights.
A novel class of drugs directly targets the glutamatergic neurotransmitter system and produces rapid antidepressant effects in some patients.
In this podcast, Dr Helen Lavretsky discusses the topic of appropriate diagnosis of mild cognitive impairment. It will be increasingly important to strengthen the definitions of what is “normal” to avoid the “pathologizing” of aging or of any individuals who experience temporary or continuous cognitive impairment.
Have you heard the news that citalopram should no longer be used at doses greater than 40 mg? Steven Moffic, MD, explores the issues surrounding this recent recommendation.
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