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Major Depressive Disorder

The Route is Key

Novel Route for Ketamine in the Treatment of MDD
This method of administration can mitigate the psychotomimetic and dissociative effects of ketamine.

Related content:
Depression Research Update

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Major Depressive Disorder

What factors predispose patients to TRD and what treatment strategies achieve response? Find out here, with a bonus case vignette.


Poetic, raw, and haunting, this young woman's description of having a psychiatric illness powerfully reveals what I believe are common, but rarely articulated, thoughts and feelings.

A low-cost intervention creates “virtual darkness” to help stabilize mood.

Insights from the first study of mortality and cumulative psychotropic exposure in schizophrenia.

Three recent studies assess the benefits of various therapies for MDD.

A safe, noninvasive method for early detection of depression could be around the corner.

A searching interrogation of scientific findings reflected against experience with patients.


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