SPOTLIGHT -
Antipsychotic Discontinuation: Two Decades Later
When patients ask, “How long should I continue antipsychotic treatment after the first episode of schizophrenia?”, consider this 20-year follow-up study.
Schizophrenia and Lifestyle: A Delicate Balance
A meta-analysis exploring factors associated with quality of life in first-episode psychosis provides guidance and take-home points for clinicians.
Inflammation and Response to ECT in Treatment-Resistant Depression
ECT is a highly effective treatment for depression, but a portion of patients fail to respond as hoped. Clinical variables have overall limited utility as a predictor of response. Is inflammation the key?
Physical Activity and Incident Depression: What the Data Tell Us
A gentle reminder to patients of all ages to “get moving” may go a long way in decreasing the risk of future depression.
Cognitive Effects of MIN-101 in Patients With Schizophrenia and Negative Symptoms
A novel compound holds promise for addressing cognitive deficits in schizophrenia.
Silver Linings After Abuse and Neglect
The neuroprotective role of resilience in patients with schizophrenia who experienced early childhood trauma is evaluated in this brief update.
Handgrip Strength and Cognitive Performance in Schizophrenia
Handgrip is a simple proxy for muscular strength and a clinically useful measure of muscular function. What are the neurophysiologic underpinnings of the relationship between handgrip strength and cognition?
Get a Grip: Strength and Cognition in Schizophrenia
Handgrip is a simple proxy for physical strength and a clinically useful measure of muscular function. What about cognitive function in patients with schizophrenia? A large study looked into just that.
Substance-Induced Psychosis and Conversion to Schizophrenia
Up to 50% of cases of cannabis-induced psychosis covert to schizophrenia. A new study provides striking evidence for abuse of other substances and schizophrenia onset.
Asthma and Risk of Schizophrenia
Is there a link between childhood and parental asthma and risk of schizophrenia?
Surgical Outcome After Arthroplasty in Patients With Schizophrenia or Bipolar Disorder
Anxiety and depression are associated with increased complications after total joint arthroplasty. Is the same true of bipolar and schizophrenic disorders?
Food Preservative for Schizophrenia?
An overview of the first study to demonstrate benefits of sodium benzoate--an NMDA enhancer--in patients with clozapine-resistant schizophrenia.
Adjunctive Cannabidiol Therapy in Schizophrenia
New research looks at the effects of CBD on positive and negative psychotic symptoms, cognitive performance, level of functioning, and the treating psychiatrist’s overall clinical impression.
Toward Biomarker-Guided Treatment in Psychosis
Is oxidative stress a therapeutic target in schizophrenia?
Olfactory Functioning in First-Episode Psychosis
What the nose knows in patients with schizophrenia.
Risk Factors for Suicidality in Patients With Schizophrenia
What are the strongest predictors of suicidality in schizophrenia?
Vitamin D Deficiency and Cognitive Functioning in Psychotic Disorders
New evidence links vitamin D status with cognition in patients with psychosis.
Mechanisms of Tardive Dyskinesia: 3-Question Quiz
Which genes have recently been associated with TD? That question and more in this quiz.
Clozapine, Mortality, and Self-Harm in Treatment-Resistant Schizophrenia
New evidence bolsters the reputation of clozapine as the “gold-standard” antipsychotic for patients with treatment-resistant schizophrenia.
A New Drug in Development for Negative Symptoms
Is an effective, well-tolerated treatment for the negative symptoms of schizophrenia on the horizon?
Recognizing Tardive Dyskinesia: A 3-Question Quiz
What factors come into play in the diagnosis of tardive dyskinesia? How is TD distinguished from other movement disorders? Find out more in this quiz.
The Gut Microbiome in First-Episode Psychosis
New findings support the involvement of microbiota alterations in psychosis-and point to novel treatments.
Pharmacologic Cotreatment in Patients With Schizophrenia
Which psychotropic combinations unlock the door to successful treatment?
Antipsychotics, Hyperprolactinemia, and Risk of Endometrial Cancer
Do prolactin-elevating antipsychotics put women at risk for endometrial cancer?
Tardive Dyskinesia Epidemiology Quiz
Which gene is not associated with risk for the development of TD? What is the prevalence of TD in patients with schizophrenia treated with antipsychotics? Those questions and more in this quiz.
Real-World Effectiveness of Antipsychotics
Which of these agents best prevents relapse? A recent study employed a novel approach to find out.
A Global Perspective on Clozapine
How widely used is this “gold-standard” antipsychotic?
Antipsychotic Response Rates Through the Prism of 60 Years
Have antipsychotic and placebo responses in acute schizophrenia changed over time?
Treatment of Metabolic Risk Factors in Patients With Psychotic Disorders
Despite increasing awareness of the cardiovascular risks, adequate treatment of the metabolic syndrome remains a persistent challenge.
The Clozapine-Infection Connection
Monitoring patients for 5 key changes can help avert drug toxicity.