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Novel Research in the Neuropsychiatry of Anorexia Nervosa

Novel Research in the Neuropsychiatry of Anorexia Nervosa

Various psychological and family dynamics contribute to anorexia nervosa (AN). From a biological standpoint, why would someone intentionally starve herself or himself to the brink of death? Research is now making progress in understanding what happens before and during the illness and how this behavior can be explained.

About once a month I meet with parents of patients in our eating disorder treatment program at Children’s Hospital Colorado to talk about how brain changes may contribute to their children’s difficulties to recover. Most of these parents have a child in whom AN has been diagnosed. My first question is whether the behavior they see in their children “makes any sense” to them. The uniform answer is no.

AN is characterized by restriction of energy intake relative to requirements, leading to a significantly low body weight for age, sex, developmental trajectory, and physical health; intense fear of gaining weight or becoming fat, even though underweight; and disturbance in the way one’s body weight or shape is experienced, undue influence of body weight or shape on self-evaluation, or denial of the seriousness of current low body weight.1

Previous research has shown that AN is associated with high premorbid and comorbid anxiety disorders.2,3 Anxious traits may make some individuals more prone to respond to environmental cues to be conscious of their weight, and they may feel a need to lose weight to be more socially accepted. High comorbid depression may also aid in this dynamic.2 Anxiety and depressive disorders frequently have been associated with the serotonin system, and in fact brain imaging studies have shown altered brain serotonin receptor availability during the ill state and after recovery. Those alterations could point to trait disturbances in the serotonin system in AN.4

Recent research in animals and humans suggests that the brain dopamine system could also be an important part of the pathophysiology of AN. This is important because brain dopamine circuits provide important signals regarding the presence and amplitude of food and other rewards as well as code the value of salient stimuli.5-8

Animal studies suggest that food restriction may sensitize, while excessive food intake may desensitize, brain reward pathways. Food restriction and weight loss seem to go along with heightened brain dopamine–related reward response in rodents, and over-consumption of food on the contrary showed addiction-like dopamine D2 receptor down-regulation.9-12

Previous research in AN indicated dopamine alterations, including altered levels of dopamine metabolites in the brain and number of dopamine receptors in specific brain regions, such as the ventral striatum, but we know little about how such alterations may be clinically important. Functional brain imaging helps bridge this gap.13-16 For instance, striatal brain response to images of thin bodies was stronger in individuals with AN than in controls.17 Individuals who recovered from AN showed reduced insular and striatal brain response to repeated sweet taste, but increased caudate response to randomly given monetary or taste stimuli.18-20


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