Psychiatric Times - Category 1 Credit
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After reading this article, you will be familiar with:
• The differences between the dementias and their causes
• Differential diagnosis of the dementias
• Treatment strategies for the dementias
• Future direction of clinical studies
Who will benefit from reading this article?
Psychiatrists, child and adolescent psychiatrists, psychologists, primary care physicians, nurse practitioners, and other health care professionals. To determine whether this article meets the continuing education requirements of your specialty, please contact your state licensing and certification boards.
1. Lyketsos CG. Dementia and milder cognitive syndromes. In: Blazer DG, Steffens DC, eds. The American Psychiatric Publishing Textbook of Geriatric Psychiatry. 4th ed. Washington, DC: American Psychiatric Publishing; 2009:chap 13.
2. Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med. 2004;256:183-194.
3. Panza F, Frisardi V, Capurso C, et al. Possible predictors of vascular cognitive impairment–no dementia. J Am Geriatr Soc. 2009;57:943-944.
4. Stephan BC, Matthews FE, Khaw KT, et al. Beyond mild cognitive impairment: vascular cognitive impairment, no dementia (VCIND). Alzheimers Res Ther. 2009;1:4.
5. Sadavoy J, Jarvik LF, Grossberg GT, Meyers BS, eds. Comprehensive Textbook of Geriatric Psychiatry. 3rd ed. New York: WW Norton; 2004.
6. Blazer DG, Steffens DC, Busse EW, eds. Essentials of Geriatric Psychiatry. Washington, DC: American Psychiatric Publishing; 2007.
7. American Psychiatric Association, Work Group on Alzheimer’s Disease and Other Dementias. Practice Guideline for the Treatment of Patients With Alzheimer’s Disease and Other Dementias. 2nd ed. Washington, DC: American Psychiatric Association; 2007. http://www.psychiatryonline.com/pracGuide/loadGuidelinePdf.aspx?file=AlzPG101007. Accessed December 25, 2009.
8. Coluccia D, Wolf OT, Kollias S, et al. Glucocorticoid therapy-induced memory deficits: acute versus chronic effects. J Neurosci. 2008;28:3474-3478.
9. Vella-Brincat J, Macleod AD. Adverse effects of opioids on the central nervous systems of palliative care patients. J Pain Palliat Care Pharmacother. 2007;21:15-25.
10. Simon RP, Greenberg DA, Aminoff MJ. Disorders of cognitive function. In: Clinical Neurology. 7th ed. New York: McGraw-Hill; 2009:chap 1.
11. Finney GR. Normal pressure hydrocephalus. Int Rev Neurobiol. 2009;84:263-281.
12. Factora R, Luciano M. When to consider normal pressure hydrocephalus in the patient with gait disturbance. Geriatrics. 2008;63:32-37.
13. Graff-Radford NR. Normal pressure hydrocephalus. Neurol Clin. 2007;25:809-832, vii-viii.
14. Aisen PS, Schneider LS, Sano M, et al; Alzheimer Disease Cooperative Study. High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial. JAMA. 2008;300:1774-1783.
15. Weir DR, Jackson JS, Sonnega A. National Football League Player Care Foundation: Study of Retired NFL Players. Institute for Social Research, University of Michigan; 2009. http://umich.edu/news/Releases/2009/Sep09/FinalReport.pdf. Accessed December 25, 2009.
16.Stone CK, Humphries RL. Head injuries. In: CURRENT Diagnosis & Treatment: Emergency Medicine. 6th ed. New York: McGraw-Hill; 2008:chap 20.
17. Simon RP. Current diagnosis and treatment of sexually transmitted diseases. In: Klausner JD, Hook EW, eds. Neurosyphilis. New York: McGraw-Hill; 2007:chap 20.
18. Bird TD. Genetic aspects of Alzheimer disease. Genet Med. 2008;10:231-239.
19. Sweet RA, Wilkosz PA. Genetics. In: Blazer DG, Steffens DC, eds. The American Psychiatric Publishing Textbook of Geriatric Psychiatry. 4th ed. Washington, DC: American Psychiatric Publishing; 2009:chap 6.
20. Kalapatapu RK, Neugroschl JA. Update on neuropsychiatric symptoms of dementia: evaluation and management. Geriatrics. 2009;64:20-26.
21. Kalapatapu RK, Schimming C. Update on neuropsychiatric symptoms of dementia: antipsychotic use. Geriatrics. 2009;64:10-18.
22. Aggarwal NT, Decarli C. Vascular dementia: emerging trends. Semin Neurol. 2007;27:66-77.
23. Wetterling T, Kanitz RD, Borgis KJ. Comparison of different diagnostic criteria for vascular dementia (ADDTC, DSM-IV, ICD-10, NINDS-AIREN). Stroke. 1996;27:30-36.
24. Wiederkehr S, Simard M, Fortin C, van Reekum R. Comparability of the clinical diagnostic criteria for vascular dementia: a critical review. Part I. J Neuropsychiatry Clin Neurosci. 2008;20:150-161.
25. Román GC, Tatemichi TK, Erkinjuntti T, et al. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology. 1993;43:250-260.
26. Mendez MF, Lauterbach EC, Sampson SM. An evidence-based review of the psychopathology of frontotemporal dementia: a report of the ANPA Committee on Research. J Neuropsychiatry Clin Neurosci. 2008;20:130-149.
27. Weder ND, Aziz R, Wilkins K, Tampi RR. Frontotemporal dementias: a review. Ann Gen Psychiatry. 2007;6:15.
28. McKhann GM, Albert MS, Grossman M, et al; Work Group on Frontotemporal Dementia and Pick’s Disease. Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick’s Disease. Arch Neurol. 2001;58:1803-1809.
29. Blass DM, Rabins PV. Depression in frontotemporal dementia. Psychosomatics. 2009;50:239-247.
30. Lippa CF, Duda JE, Grossman M, et al; DLB/PDD Working Group. DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers. Neurology. 2007;68:812-819.
31. Dodel R, Csoti I, Ebersbach G, et al. Lewy body dementia and Parkinson’s disease with dementia. J Neurol. 2008;255(suppl 5):39-47.
32. McKeith IG, Dickson DW, Lowe J, et al; Consortium on DLB. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium [published correction appears in Neurology. 2005;65:1992]. Neurology. 2005;65:1863-1872.
33. Burn DJ. Cortical Lewy body disease and Parkinson’s disease dementia. Curr Opin Neurol. 2006;19:572-579.
34. Hanson JC, Lippa CF. Lewy body dementia. Int Rev Neurobiol. 2009;84:215-228.
35. Truong DD, Bhidayasiri R, Wolters E. Management of non-motor symptoms in advanced Parkinson disease. J Neurol Sci. 2008;266:216-228.
36. Emre M, Aarsland D, Brown R, et al. Clinical diagnostic criteria for dementia associated with Parkinson’s disease. Mov Disord. 2007;22:1689-1707; quiz 1837.
37. Park A, Stacy M. Non-motor symptoms in Parkinson’s disease. J Neurol. 2009;256(suppl 3):293-298.
38. Weintraub D, Comella CL, Horn S. Parkinson’s disease—part 3: neuropsychiatric symptoms. Am J Manag Care. 2008;14(2 suppl):S59-S69.
39. Miyasaki JM, Shannon K, Voon V, et al; Quality Standards Subcommittee of the American Academy of Neurology. Practice parameter: evaluation and treatment of depression, psychosis, and dementia in Parkinson disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2006;66:996-1002.
40. Walker FO. Huntington’s disease. Semin Neurol. 2007;27:143-150.
41. Montoya A, Price BH, Menear M, Lepage M. Brain imaging and cognitive dysfunctions in Huntington’s disease. J Psychiatry Neurosci. 2006;31:21-29.
42. Mestre T, Ferreira J, Coelho MM, et al. Therapeutic interventions for symptomatic treatment in Huntington’s disease. Cochrane Database Syst Rev. 2009;(3):CD006456.
43. Mestre T, Ferreira J, Coelho MM, et al. Therapeutic interventions for disease progression in Huntington’s disease. Cochrane Database Syst Rev. 2009;(3):CD006455.
44. Cardoso F. Huntington disease and other choreas. Neurol Clin. 2009;27:719-736, vi.
45. American Academy of Neurology Guideline Summary for Clinicians: Detection, Diagnosis, and Management of Dementia. http://www.aan.com/professionals/practice/pdfs/dementia_guideline.pdf. Accessed December 25, 2009.
46. Kalapatapu RK, Chambers R. Novel objective biomarkers of alcohol use: potential diagnostic and treatment management tools in dual diagnosis care. J Dual Diagn. 2009;5:57-82.
47. American Psychiatric Association, Work Group on Delirium. Practice Guideline for the Treatment of Patients With Delirium. Washington, DC: American Psychiatric Association; 1999. http://www.psychiatryonline.com/pracGuide/loadGuidelinePdf.aspx?file=Delirium_Inactivated_04-16-09. Accessed December 25, 2009.
48. Welsh-Bohmer K, Attix DK. Neuropsychological assessment of dementia. In: Blazer DG, Steffens DC, eds. The American Psychiatric Publishing Textbook of Geriatric Psychiatry. 4th ed. Washington, DC: American Psychiatric Publishing; 2009:chap 11.
49. Shah RS, Lee HG, Xiongwei Z, et al. Current approaches in the treatment of Alzheimer’s disease. Biomed Pharmacother. 2008;62:199-207.
50. Solomon PR, Murphy CA. Early diagnosis and treatment of Alzheimer’s disease. Expert Rev Neurother. 2008;8:769-780.
51. van Marum RJ. Current and future therapy in Alzheimer’s disease. Fundam Clin Pharmacol. 2008;22:265-274.
52. Okura Y, Matsumoto Y. DNA vaccine therapy for Alzheimer’s disease: present status and future direction. Rejuvenation Res. 2008;11:301-308.
53. Gong CX, Iqbal K. Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease. Curr Med Chem. 2008;15:2321-2328.
54. Salloway S, Mintzer J, Weiner MF, Cummings JL. Disease-modifying therapies in Alzheimer’s disease. Alzheimers Dement. 2008;4:65-79.
55. Jellinger KA. The pathology of “vascular dementia”: a critical update. J Alzheimers Dis. 2008;14:107-123.
56. Trojanowski JQ, Duff K, Fillit H, et al; Frontotemporal Dementia (FTD) Working Group on FTD Drug Discovery. New directions for frontotemporal dementia drug discovery. Alzheimers Dement. 2008;4:89-93.
57. Farlow MR, Cummings J. A modern hypothesis: the distinct pathologies of dementia associated with Parkinson’s disease versus Alzheimer’s disease. Dement Geriatr Cogn Disord. 2008;25:301-308.
58. Lee SJ. Origins and effects of extracellular alpha-synuclein: implications in Parkinson’s disease. J Mol Neurosci. 2008;34:17-22.
59. Imarisio S, Carmichael J, Korolchuk V, et al. Huntington’s disease: from pathology and genetics to potential therapies. Biochem J. 2008;412:191-209.