Brian Miller, MD, PhD, MPHFeb 06, 2017Featured Resources›SchizophreniaIntegrative Psychiatry Can dietary supplementation decrease the risk of transition to psychosis? Scroll through the slides to see what the research tells us. Ultrahigh-risk psychosis is described as potential prodromal psychotic symptoms and/or familial liability to psychosis. A study by Amminger and colleagues found that dietary supplementation with long-chain omega-3 polyunsaturated fatty acids was superior to placebo. In a a multisite randomized clinical trial, McGorry and colleagues attempted to replicate the association between ω-3 PUFAs and decreased risk of transition to psychosis.