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Ultrahigh-Risk Psychosis: Do Things Come in (Omega)-3s?

Ultrahigh-Risk Psychosis: Do Things Come in (Omega)-3s?

  • Can dietary supplementation decrease the risk of transition to psychosis? Scroll through the slides to see what the research tells us.
  • Ultrahigh-risk psychosis is described as potential prodromal psychotic symptoms and/or familial liability to psychosis.
  • A study by Amminger and colleagues[1] found that dietary supplementation with long-chain omega-3 polyunsaturated fatty acids was superior to placebo.
  • In a a multisite randomized clinical trial, McGorry and colleagues[2] attempted to replicate the association between ω-3 PUFAs and decreased risk of transition to psychosis.


A pleasure to read these results. The quality of presentation was super (i.e., compelling and easy to follow). And hats off to Psychiatric Times for provide a forum for findings such as these.

Assuming there is a reason omega-3 should be particularly helpful in this area, please keep thinking on this. For me reading through the first time, the exclusion list seemed rather extensive. Could a significant omega-3 factor have been removed at that stage? For example, could exclusion of socially-marginalized folks actually delete those at risk for a malnutrition issue - something which omega-3 might stave off in a full population at high-risk for emergent psychosis.

Bob @

Thank you for sharing your study. I'm wondering about the use of the term "ultrahigh-risk psychosis"- It seems like ultrahigh risk FOR psychosis is more accurate.

Tamara @

Vitamins and herbs are drugs and interact with antipsychotics and levels of psychosis...like grapefruit interacts with statins and garlic interacts with anticoagulants. There are side effects. Nothing replaces monitoring, ethical research, consent, and care.

Brenda E @

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