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James Phelps, MD

James Phelps, MD

James Phelps, MD, is Director of the Mood Disorders Program at Samaritan Mental Health in Corvallis, Ore. He is the Bipolar Disorder Section Editor for Psychiatric Times. His Web site, PsychEducation.org, gathers no information on visitors and produces no income for him or others. He is the author of Why Am I Still Depressed? Recognizing and Managing the Ups and Downs of Bipolar II and Soft Bipolar Disorder (New York: McGraw-Hill; 2006), from which he receives royalties. Dr Phelps stopped accepting honoraria from pharmaceutical companies in 2008.

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In the treatment of depression, clinicians are often faulted for failing to give an antidepressant medication at a high enough dose. What is high enough? Answering this question turns out to be tricky.

Striking findings on the relationship between stress and depression.

Experts summarize data on the role of inflammation in psychiatric disorders, emphasizing that evidence for anti-inflammatory treatment for mood disorders is limited, and mixed.

The SRT polymorphism is one of the most well studied genetic variations affecting mood disorders. Once personal genetic information is readily available, can we help patients understand the implications of their results?

Is prevention of bipolar disorder possible? What happens before a manic or hypomanic episode that identifies this illness? Researchers asked whether there are any signs or symptoms that predict later diagnosable bipolar disorder with reasonable accuracy.

Do we really have another antipsychotic in the offing, one with a completely different mechanism than existing agents? Here: existing evidence regarding the effects of cannabidiol.

Must clinicians presume that all their female patients of reproductive age are potentially going to become pregnant? And if so, what treatment option should be offered?

An instructive case that ties in to an APA presentation on "Treatment and Research of Treatment-Resistant Depression and Bipolar Disorder."

The Neural Basis of Bipolar Disorder

Selected for clinical implications, here are some highlights from the recent acceleration in understanding of the mechanisms of bipolar disorder.

The authors—both well-known specialists—attempt to integrate the two fundamental ingredients of psychotherapy and pharmacology in the treatment of bipolar disorders.


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