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Larry D. Alphs, PhD

Larry D. Alphs, PhD

Dr Alphs is Therapeutic Area Leader in Psychiatry, Medical and Scientific Affairs, for Janssen, LP, Ortho-McNeil Janssen Scientific Affairs, LLC, Titusville, NJ.

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Negative symptoms identified from the Negative Symptom Assessment and the behaviors that might be observed in each of 5 domains.

What signs are generally regarded as negative symptoms? What etiological factors contribute to a negative symptom presentation? How to treat these symptoms? Insights here.

Treatment of negative symptoms of schizophrenia -- eg, problems with motivation, social withdrawal, diminished affective responsiveness, speech, and movement -- is associated with a variety of improved functional outcomes and is a vital unmet clinical need.

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