Mood Disorders

Neuropsychopharmacology, the official publication of the American College of Neuropsychopharmacology, publishing the highest quality original research and advancing our understanding of the brain and behavior.

J Neurol Neurosurg Psychiatry. doi: 10.1136/jnnp-2011-300980. Movement disorders. Review. Visual hallucinations in the differential diagnosis of parkinsonism. ... Most published reports included patients referred to specialist movement disorders clinics

Archives of General Psychiatry, a monthly professional medical journal published by the American Medical Association, publishes original, peer-reviewed articles about psychiatry and related fields

Is a Severe Clinical Profile an Effect Modifier in a Web-Based Depression Treatment for Adults With Type 1 or Type 2 Diabetes? Secondary Analyses From a Randomized Controlled Trial|Background: Depression and diabetes are two highly prevalent and co-occurring health problems. Web-based, diabetes-specific cognitive behavioral therapy (CBT) depression treatment is effective in diabetes patients, and has the potential to be cost effective and to have large reach. A remaining question is whether the effectivene

NotesCite this as: BMJ 2011;343:d7789

Bipolar depression is often refractory to treatment and is frequently associated with anxiety symptoms and elevated suicide risk. There is a great need for adjunctive psychotherapeutic interventions. Treatments with effectiveness for depressive and anxiety symptoms as well as suicide-related thoughts and behaviors would be particularly beneficial. Mindfulness-based interventions hold promise, and studies of these approaches for bipolar disorder are warranted. The aim of this paper is to provide a conceptual background for such studies by reviewing key findings from diverse lines of investigation. Results of that review indicate that cortical midline structures (CMS) appear to link abnormal self-referential thinking to emotional dysregulation in mood disorders. Furthermore, CMS and striatal dysfunction may play a role in the neuropathology underlying suicide-related thoughts and behaviors. Thus, combining studies of mindfulness interventions targeting abnormal self-referential thinking

To investigate the validity of the Chinese version of Mood Disorder Questionnaire (C-MDQ) in China. Patients with bipolar disorders (BP, N=284) and patients with unipolar depressive disorder (UP, N=134) were assessed with the C-MDQ. The Eigenvalues of the first two factors were 3.15 and 2.09, respectively. The Cronbach's alpha of the C-MDQ was 0.79. The frequency of positive responses of UP patients was significantly lower than those of BP patients for 12 items except the seventh item. A C-MDQ screening score of seven or more was the best cutoff between BP and UP. The C-MDQ could distinguish between bipolar II disorder (BP-II) and UP, and the best cutoff was five. A cutoff of five had a sensitivity of 0.80 and a specificity of 0.54 between BP and UP. This study demonstrated the good validity of C-MDQ in China. The best cutoff between BP-II and UP can be regarded as the optimal cutoff between BP and UP to improve the sensitivity of screening for BP-II. Five should be the optimal cutoff

In the last decades the concept of bipolar disorder was subjected to many revisions. The complexity in diagnosing mood disorders, on the other hand, stems from the problem to delineate the boundary of these morbid conditions. The current nosographic approach is limited by the lack of attention given to the natural course and to the longitudinal and family characteristics of patients suffering of mood disorders. Considering these limits, some authors developed different nosographic models to include other atypical, non-standardized characteristics of mood disorders. However, regardless of the efforts made so far, a gap in classification still remains, putting restrictions in the clinical and neurobiological range of activities.

Maternal adaptations, such as decreased anxiety and attenuated stress responsiveness, are necessary to enable successful postnatal development of the offspring. However, there is growing evidence that they are also required to protect the mental health of the mother and that exposure to chronic stress during pregnancy may prevent such adaptations. Overcrowding stress (24 h) and restraint stress (2 1 h) were employed on alternate days between pregnancy d 4-16 to examine the impact of chronic pregnancy stress on relevant behavioral, neuroendocrine, and neuronal peripartum adaptations. To determine whether the chronic stress-induced alterations were specific to the peripartum period, we included virgins as controls. Validating the stress procedure, we demonstrated decreased body-weight gain and increased adrenal weight in stressed dams, relative to their nonstressed controls. Chronic stress prevented a number of peripartum adaptations, including basal plasma hypercorticosterone levels,

Four-hundred and twenty three consecutive patients who have been seen in a private psychiatric clinic were assessed for bipolar disorder. A large proportion of these patients were found to demonstrate a number of somatic syndromes. The main somatic syndromes found on the patients' "first visit" have been: colitis (45% of the patients), gastritis (25%), migraine (8%) others (above all with dermatological symptoms: 2%). All the patients presented muscular tension at their "first visit". Somatic syndromes constitute an important pointer for the diagnosis of bipolar spectrum disorders.

Mood, memory, and cognition. In: Menopause and osteoporosis update 2009.

Reviews the evidence for and against hundreds of preventive health services, recommending tests, and counseling interventions when evidence exists that it is effective.

Practice parameter for the assessment and treatment of children and adolescents with bipolar disorder.