
Ketamine Infusion for Alcohol Use Disorder
Researchers tested the effects of ketamine combined with motivational enhancement therapy in adults drinking 5 alcoholic beverages per day.
NEWS BRIEF
Participants were randomized to either
Following administration, alcohol use was assessed with abstinence, confirmed by urine ethyl glucuronide testing. A longitudinal model was used to gauge daily abstinence from alcohol over 21 days following ketamine administration.
Compared with midazolam, the ketamine infusion significantly improved abstinence. Moreover, it delayed the time to relapse and reduced the likelihood of heavy drinking days. Infusions were well tolerated, with no discontinuations due to adverse effects.
References:
1. Dakwar E, Levin F, Hart CL, et al.
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