Mood Disorders

Review the highlights from last week's meeting of the American Society for Clinical Psychopharmacology.

Luvesilocin enters phase 2, hinting at lasting relief after 1–2 doses and a new 5-HT2A model.

Investigational depression drugs target SIRT6 epigenetics, histamine H3, and AMPA.

Psychiatrist Gus Alva highlights new depression therapies, neuromodulation, and why screening for bipolar disorder prevents antidepressant harm.

Learn why insomnia and daytime sleepiness signal psychiatric risk, and how screening for apnea, delayed phase, and fatigue sharpens treatment.

Learn more about strategies for deprescribing, and the importance of finding the most effective medication possible.

Real-world registry data reveals young adults with mood disorders face high TD burden yet low diagnosis rates, spotlighting urgent screening gaps.

Learn more about medication use in pregnancy and postpartum, including risks and benefit analysis.

MRI-guided SAINT TMS aims to remit treatment-resistant depression in days.

Studies link compassion and wisdom to less loneliness and richer gut microbiome diversity, pointing to gut–brain targets for mental health interventions.

Guidance on psychotropic meds in pregnancy: personalize decisions, coordinate care, and plan early to prevent postpartum relapse.

Planning for prevention of perinatal psychiatric relapse with safer medication options.

Discover APA sessions on OCD therapies, gut-brain microbiome insights, AI, sports psychiatry, and geriatric updates from top clinicians.

Experts discuss rapid cycling and bipolar II, and weigh lithium as an often overlooked treatment option.

Learn how genetics shape psych med response and dosing.

Explore how neuromelanin-sensitive MRI noninvasively tracks long-term dopamine and noradrenaline system changes.

Clinicians explore neuroscience-guided off-label prescribing.

Round on the latest news in psychiatry from the last week.

Psychiatry experts explain why off-label psych meds and polypharmacy can be essential.

Learn why patients skip psych meds and how to boost adherence with stigma-free dialogue, routine hacks, family support, and deprescribing tips.

New evidence shows lithium adds minimal weight in bipolar disorder and explains why some gain occurs—plus practical tips to prevent it.

Bupropion may cause dose-linked tinnitus; this case shows symptoms improve after dose reduction, helping manage depression without stopping treatment.

BPL-003 phase 2a part 2 results show reductions in depression symptoms.

Bipolar and spring mania: tips from an expert.

New Sleep in America poll reveals kids fall short on sleep, parents underestimate needs, and family wellbeing suffers.