
This series examines how clinicians can move patients with major depressive disorder from response to true remission. This series covers recognizing overlooked and underreported symptoms, setting patient-defined treatment goals, the strengths and limits of rating scales, monitoring progress through everyday conversation, residual symptoms such as anhedonia and sleep disturbance, the switch-versus-augment decision, selecting an adjunctive atypical antipsychotic based on tolerability and individual risk factors, and emerging treatments including rapid-acting agents and psychedelics.











