Vol 30 No 9

Inflammation and Treatment Resistance in Major Depression: The Perfect Storm

September 12, 2013

New findings provide powerful evidence that inhibition of inflammation or its downstream effects on mood may open up a host of new approaches to treatment for depression, especially for patients with treatment-resistant depression.

Augmentation Strategies in MDD Therapy

September 11, 2013

For many patients with depression, full symptom remission remains elusive despite multiple trials of antidepressants. This article focuses on psychopharmacological and related interventions.

Introduction: Treatment Along the Life Cycle

September 11, 2013

The diagnosis and management of unipolar depression remain challenging. The articles in this Special Report remind us of the wide knowledge base that is needed in the management of the depressed patient and of the multiple conceptual levels that must be integrated in the care of our patients.

Depression-Related Disparities Among Older, Low-Acculturated US Latinos

September 11, 2013

Older Latinos with depression report higher levels of impairment and are more persistently ill than non-Hispanic white older adults, yet they have lower rates of guideline-concordant treatment. Cognitive and problem-solving psychosocial modalities are emerging as key treatment considerations for older Latinos.

Special Issues in Menopause and Major Depressive Disorder

September 11, 2013

A risk to benefit ratio of treatment must be established to determine the optimal treatment for perimenopausal depression. Untreated depression during the perimenopause exacerbates heart disease, diabetes, and osteoporosis. Details about management options here.

Mind-Body Interventions for Mood Disorders in Older Adults

September 09, 2013

Nonpharmacological interventions-such as mind-body interventions-can improve a partial response to antidepressants via stress reduction, improved physical functioning, increased socialization, and reduced risks of polypharmacy.