
Poll: Do You Feel Prepared to Prescribe the Newly Approved First-In-Class Muscarinic Agonist?
Key Takeaways
- Cobenfy, targeting M1 and M4 receptors, is the first novel schizophrenia treatment in decades, avoiding D2 receptor blockade.
- The approval is a significant milestone, potentially changing the treatment paradigm for schizophrenia.
The first-in-class muscarinic agonist Cobenfy, formerly known as KarXT, was just approved by the FDA to treat schizophrenia in adults. Are you ready to discuss it with patients and caregivers?
On September 26, 2024, the US Food and Drug Administration
The landmark decision brings excitement to the field. “[The] landmark approval of our first-in-class treatment for schizophrenia marks an important milestone for the community, where after more than 30 years, there is now an entirely new pharmacological approach for schizophrenia — one that has the potential to change the treatment paradigm,” Chris Boerner, PhD , board chair and chief executive officer at Bristol Myers Squibb said in a press release.1 “As we reenter the field of neuropsychiatry, we are dedicated to changing the conversation around serious mental illness, beginning with today’s approval in schizophrenia.”
Although Psychiatric Times and other medical publications have
How confident and prepared are you to discuss and prescribe Cobenfy and future muscarinic agonists?
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Reference
1. U.S. Food and Drug Administration Approves Bristol Myers Squibb’s COBENFY™ (xanomeline and trospium chloride), a First-In-Class Muscarinic Agonist for the Treatment of Schizophrenia in Adults. BMS. Press release. September 26, 2024. Accessed September 27, 2024. https://news.bms.com/news/corporate-financial/2024/U.S.-Food-and-Drug-Administration-Approves-Bristol-Myers-Squibbs-COBENFY-xanomeline-and-trospium-chloride-a-First-In-Class-Muscarinic-Agonist-for-the-Treatment-of-Schizophrenia-in-Adults/default.aspx
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