Author | Michael E. Thase, MD


Solving Clinical Challenges in Major Depression

September 18, 2017


Grief vs depression? MDD vs depressive episodes? SGAs in treatment-resistant depression? Treatment-emergent sexual dysfunction? Insights in this Q&A.

Atypical Depression in the 21st Century: Diagnostic and Treatment Issues

November 20, 2012


Identification of atypical features is important in the treatment of depression for both treatment selection and prognosis, especially when initial measures prove ineffective. The concept of atypical depression has evolved over many years, and now it appears timely for a further revision.

Update on the Treatment of Bipolar Depression

November 05, 2012


There are many rapidly effective treatments for mania in bipolar disorder. However, there are relatively few options for bipolar depression, and none that are rapidly effective-even though bipolar depression constitutes between 20% to 50% of all depressive disorders.

Podcast: Cognitive Behavior Therapy for Severe Mental Illness

May 02, 2012


Dr Michael Thase touches on an APA presentation about newer applications of cognitive therapy for disorders such as schizophrenia and bipolar disorder.

Combining High-Yield CBT Methods and Pharmacotherapy in Brief Sessions

November 02, 2010


There is evidence that the combination of medication and psychotherapy improves outcomes for many psychiatric illnesses. Among the several forms of psychotherapy that might be considered, cognitive-behavioral therapy (CBT) is the most extensively studied.

Book Review: Cognitive Behavioral Therapy for Clinicians

October 01, 2006


CBT is a comprehensive system of therapy that builds on core therapeutic values by using a wide range of reliable methods to produce cognitive and behavioral change.

Small Effects Are Not Trivial From a Public Health Perspective

September 01, 2002


Our perceptions about antidepressant efficacy have been inflated by the "file drawer" effect: the selective publication of positive studies and suppression of negative ones.