Michael E. Thase, MD


Atypical Depression in the 21st Century: Diagnostic and Treatment Issues

November 20, 2012

Identification of atypical features is important in the treatment of depression for both treatment selection and prognosis, especially when initial measures prove ineffective. The concept of atypical depression has evolved over many years, and now it appears timely for a further revision.

Update on the Treatment of Bipolar Depression

November 06, 2012

There are many rapidly effective treatments for mania in bipolar disorder. However, there are relatively few options for bipolar depression, and none that are rapidly effective-even though bipolar depression constitutes between 20% to 50% of all depressive disorders.

Combining High-Yield CBT Methods and Pharmacotherapy in Brief Sessions

November 02, 2010

There is evidence that the combination of medication and psychotherapy improves outcomes for many psychiatric illnesses. Among the several forms of psychotherapy that might be considered, cognitive-behavioral therapy (CBT) is the most extensively studied.

Book Review: Cognitive Behavioral Therapy for Clinicians

October 01, 2006

CBT is a comprehensive system of therapy that builds on core therapeutic values by using a wide range of reliable methods to produce cognitive and behavioral change.

Small Effects Are Not Trivial From a Public Health Perspective

September 01, 2002

Our perceptions about antidepressant efficacy have been inflated by the "file drawer" effect: the selective publication of positive studies and suppression of negative ones.