Tsung-Ping Su, PhD




Understanding the Role of Sigma-1 Receptors in Psychotic Depression

October 01, 2005

Selective serotonin reuptake inhibitors have been shown effective in the treatment of depression with psychosis. This efficacy appears to correlate with the SSRIs’ level of affinity at the sigma-1 receptors in the brain. What role does the sigma-1 receptor play in psychotic depression? Based on this role, are there implications for other treatments?