A University of Pittsburgh team led by Dr Mary Phillips has contributed tremendously toward a lab test that would differentiate unipolar depression from bipolar depression. In a recent review of their own and others’ work, Drs Cardoso de Almeida and Phillips noted that there are indeed differences that can be seen on MRI.

A. More widespread abnormalities in white matter connectivity in BP

B. More white matter hyperintensities in BP 

D. Abnormally reduced amygdala activity to mild sad and neutral facial expressions in BP 

Answer: D Abnormally reduced amygdala activity to mild sad and neutral facial expressions in BP. (The MRI showed abnormally increased amygdala activity.)