
Drugs vs Psychotherapy for MDD: Patient’s Choice?
A new finding that may help optimize the treatment of major depressive disorder.
RESEARCH UPDATE
Since primary care physicians have taken the lead in the diagnosis and initial treatment of MDD, pharmacotherapy has generally become the first line of defense. Recently, however, a
Only about half of persons with major depression seek help each year. Of those who do and receive a prescription for pharmacotherapy, 20% do not fill their prescription, and many of those who do fill their prescriptions
A comprehensive literature search spanning 25 years turned up 11 randomized, controlled trials that compared a second-generation antidepressant with CBT. Ten of these trials compared antidepressant monotherapy with CBT alone, and 3 compared
Benefits were measured in relation to response and remission, including time to response or remission, relapse, quality of life, functioning, suicidal ideation or behaviors, and hospital admission. Harms were measured in relation to overall and serious adverse events; specific adverse events, including hyponatremia, seizures,
Equivalent benefits/harms found
No statistically significant differences between second-generation antidepressants and CBT were found for treatment response (pooled rate, 44% vs 46%; risk ratio [RR], 0.91; 95% confidence interval [CI], 0.77 - 1.07), remission (pooled rate, 41% vs 48%; RR, 0.9; 95% CI, 0.73 - 1.32), or change in Hamilton Rating Scale for Depression scores at 8 weeks (weighted mean difference, −0.38; 95% CI, −2.87 - 2.10). No significant differences in overall study discontinuation rates were found either, including discontinuation due to lack of efficacy.
Although more patients who received pharmacotherapy withdrew from the trials because of adverse events, compared with those who received CBT, the difference was not statistically significant (RR, 3.29; 95% CI, 0.42 - 25.72). The findings held true for
The strength of evidence in the individual trial outcomes reviewed was low to moderate; thus,
Conclusion
The most efficient option for the treatment of first-episode MDD, therefore, may simply be to follow the patient’s preference. Studies show that patients who are allowed to follow their treatment preferences
References:
1. Amick HR, Gartlehner G, Gaynes BN, et al. Comparative benefits and harms of second generation antidepressants and cognitive behavioral therapies in initial treatment of major depressive disorder: systematic review and meta-analysis. BMJ. 2015;351:h6019.
2. Xing S, Dipaula BA, Lee HY, et al. Failure to fill electronically prescribed antidepressant medications: a retrospective study. Prim Care Companion CNS Disord. 2011;13:pii: PCC.10m00998.
3. Raue PJ, Schulberg HC, Heo M, et al. Patients’ depression treatment preferences and initiation, adherence, and outcome: a randomized primary care study. Psychiatr Serv. 2009;60:337-343.
4. Mergl R, Henkel V, Allgaier AK, et al. Are treatment preferences relevant in response to serotonergic antidepressants and cognitive-behavioral therapy in depressed primary care patients? Results from a randomized controlled trial including a patients’ choice arm. Psychother Psychosom. 2011;80:39-47.
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